The CD163 Polyclonal Antibody (CAB23023) is a versatile tool for researchers studying CD163, a cell surface protein known for its role in immune regulation and inflammation. This antibody, produced in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding to the CD163 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for immunology and cancer research studies.CD163, a member of the scavenger receptor cysteine-rich superfamily, plays a crucial role in regulating immune responses and resolving inflammation.
Its involvement in various diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions underscores its importance as a potential therapeutic target. By understanding the functions of CD163, researchers can develop targeted treatments that modulate immune responses effectively in disease contexts. Overall, the CD163 Polyclonal Antibody offers researchers a valuable tool for investigating CD163 protein expression and function, ultimately contributing to advancements in the fields of immunology and cancer research.
Product Name:
CD163 Polyclonal Antibody
SKU:
CAB23023
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 42-261 of human CD163 (NP_004235.4?).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
125kDa
Observed MW:
160kDa
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
9332
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and 293T cells transfected with CD63 using CD163 Rabbit pAb (CAB23023) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
