Description
IL17D Antibody (PACO07421)
The IL17D Polyclonal Antibody (PACO07421) is a vital tool for researchers studying IL17D, a cytokine involved in immune regulation and inflammation. This antibody, produced in rabbits, is highly specific to IL17D in human samples and is validated for use in Western blot and immunohistochemistry applications. By binding to IL17D, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in immunology, inflammation, and cancer research.IL17D, a member of the Interleukin-17 family, plays a key role in regulating immune responses and maintaining tissue homeostasis. It has been implicated in autoimmune diseases, inflammatory disorders, and cancer progression, making it a promising target for drug development and therapeutic interventions.
Understanding the function of IL17D is crucial for unraveling its complex roles in immune modulation and disease pathogenesis. Overall, the IL17D Polyclonal Antibody (PACO07421) provides researchers with a reliable tool for studying the biological functions of IL17D and its potential implications in various disease states. Its high specificity and sensitivity make it a valuable asset for advancing scientific knowledge and exploring new avenues for treatment strategies.
| Antibody Name: | IL17D Antibody (PACO07421) |
| Antibody SKU: | PACO07421 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:10000-1:20000, IHC-p:1:50-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide from human protein at AA range: 141-190 |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100. |
 | Immunohistochemical analysis of paraffin-embedded Human-brain, antibody was diluted at 1:100. |
 | Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100. |
| Synonyms: | Interleukin-17D (IL-17D) (Interleukin-27) (IL-27) |
| UniProt Protein Function: | IL17D: Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Belongs to the IL-17 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 13q11 Cellular Component: extracellular space Molecular Function:cytokine activity; hematopoietin/interferon-class (D200-domain) cytokine receptor binding Biological Process: cell surface receptor linked signal transduction; inflammatory response |
| NCBI Summary: | The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TAD2 |
| NCBI GenInfo Identifier: | 46576614 |
| NCBI Gene ID: | 53342 |
| NCBI Accession: | Q8TAD2.1 |
| UniProt Secondary Accession: | Q8TAD2,B1AM69, |
| UniProt Related Accession: | Q8TAD2 |
| Molecular Weight: | 21,893 Da |
| NCBI Full Name: | Interleukin-17D |
| NCBI Synonym Full Names: | interleukin 17D |
| NCBI Official Symbol: | IL17DÂ Â |
| NCBI Official Synonym Symbols: | IL-17DÂ Â |
| NCBI Protein Information: | interleukin-17D |
| UniProt Protein Name: | Interleukin-17D |
| UniProt Synonym Protein Names: | Interleukin-27 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL17DÂ Â |
| UniProt Entry Name: | IL17D_HUMAN |
