The KIR2DL5A/KIR2DL5B Monoclonal Antibody (PACO07414) is a valuable tool for research involving the KIR2DL5A and KIR2DL5B proteins, which are members of the killer cell immunoglobulin-like receptor (KIR) family. These proteins play a crucial role in the regulation of natural killer (NK) cell activity and have been implicated in various immune responses, including viral infections and tumor surveillance.This monoclonal antibody, generated in mice, exhibits high specificity and sensitivity for detecting KIR2DL5A and KIR2DL5B in human samples. Validated for use in applications such as immunohistochemistry and flow cytometry, this antibody enables researchers to investigate the expression and function of these KIR proteins in different cell populations.
Studying KIR2DL5A and KIR2DL5B is essential for gaining insights into the mechanisms underlying NK cell-mediated immune responses and their implications in diseases such as cancer and viral infections. By targeting these KIR proteins, researchers may uncover new therapeutic strategies for modulating NK cell activation and enhancing immune surveillance against pathogens and malignant cells.
Antibody Name:
KIR2DL5A/KIR2DL5B Antibody (PACO07414)
Antibody SKU:
PACO07414
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:10000-1:20000, IHC-p:1:50-1:300
Species Reactivity:
Human
Immunogen:
Synthetic peptide from human protein at AA range: 31-80
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method:
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100.
Immunohistochemical analysis of paraffin-embedded Human-tonsil, antibody was diluted at 1:100.
UniProt Protein Function:
Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
UniProt Protein Details:
NCBI Summary:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
