Description
LAMA5 Antibody (PACO27901)
The LAMA5 Antibody (PAC027901) is a valuable tool for researchers studying LAMA5, a key component of the extracellular matrix that plays a critical role in cell adhesion, migration, and signaling. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is suitable for use in various applications, including Western blotting.LAMA5, also known as laminin alpha 5, is involved in tissue development and maintenance, making it essential for processes such as embryogenesis, wound healing, and angiogenesis. Dysregulation of LAMA5 has been linked to various diseases, including cancer, cardiovascular conditions, and neurological disorders, highlighting its importance as a therapeutic target.
By targeting LAMA5 with this antibody, researchers can investigate its expression levels, localization, and interactions in different cell types and tissues. This allows for a better understanding of the role of LAMA5 in normal physiology and disease pathogenesis, potentially leading to the development of novel diagnostic and therapeutic strategies.
| Antibody Name: | LAMA5 Antibody (PACO27901) |
| Antibody SKU: | PACO27901 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Laminin subunit alpha-5 protein (3401-3692AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO27901 at dilution of 1:100. |
| Background: | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| Synonyms: | Laminin subunit alpha-5 (Laminin-10 subunit alpha) (Laminin-11 subunit alpha) (Laminin-15 subunit alpha), LAMA5, KIAA0533 KIAA1907 |
| UniProt Protein Function: | LAMA5: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Extracellular matrix; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q13.2-q13.3 Cellular Component: extracellular matrix; extracellular space; laminin-5 complex; laminin-1 complex; laminin-10 complex; extracellular region; basement membrane; basal lamina; nucleus Molecular Function:integrin binding; structural molecule activity Biological Process: integrin-mediated signaling pathway; regulation of cell adhesion; focal adhesion formation; endothelial cell differentiation; extracellular matrix organization and biogenesis; muscle development; cell migration; regulation of embryonic development; cell recognition; cytoskeleton organization and biogenesis; regulation of cell migration; regulation of cell proliferation; odontogenesis of dentine-containing teeth; cell proliferation; extracellular matrix disassembly; embryonic development; morphogenesis of embryonic epithelium; hair follicle development; ureteric bud branching; cilium biogenesis; angiogenesis; cell differentiation; neural crest cell migration; morphogenesis of a polarized epithelium; lung development |
| NCBI Summary: | This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013] |
| UniProt Code: | O15230 |
| NCBI GenInfo Identifier: | 21264602 |
| NCBI Gene ID: | 3911 |
| NCBI Accession: | |
| UniProt Related Accession: | O15230 |
| Molecular Weight: | |
| NCBI Full Name: | laminin subunit alpha-5 |
| NCBI Synonym Full Names: | laminin subunit alpha 5 |
| NCBI Official Symbol: | LAMA5Â Â |
| NCBI Protein Information: | laminin subunit alpha-5 |
| UniProt Protein Name: | Laminin subunit alpha-5 |
| UniProt Synonym Protein Names: | Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha |
| UniProt Gene Name: | LAMA5Â Â |
| UniProt Entry Name: | LAMA5_HUMAN |
| Antibodies | ELISA Kits |
| LAMA5 Antibody (PACO02865) | Human Laminin subunit alpha-5 / LAMA5 ELISA Kit |
| Human Laminin subunit alpha-5 (LAMA5) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
