The PCDHB15 Polyclonal Antibody (PAC020191) is a vital tool for researchers studying PCDHB15, a member of the protocadherin beta gene cluster that is involved in cell-cell adhesion and signaling. This antibody, produced using rabbits, demonstrates high specificity and sensitivity in detecting PCDHB15 in human samples, making it suitable for use in Western blot applications. By binding to the PCDHB15 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for investigations in developmental biology and neuroscience.
PCDHB15, a cell adhesion molecule, plays a crucial role in neuronal development and connectivity by mediating cell-cell interactions and promoting neuronal circuit formation. Its involvement in neuronal patterning and synapse formation highlights its importance in brain development and function. Research into the functions of PCDHB15 can provide valuable insights into neural development, synaptic plasticity, and neurological disorders. Therefore, the PCDHB15 Polyclonal Antibody is a valuable tool for unraveling the complexities of neural circuitry and brain function.
Antibody Name:
PCDHB15 Antibody (PACO20191)
Antibody SKU:
PACO20191
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PCDHB15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20191(PCDHB15 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20191(PCDHB15 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the protocadherin β gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The β cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections.
Synonyms:
protocadherin β 15
UniProt Protein Function:
PCDHB15: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
