The PCP4 Polyclonal Antibody (PAC013791) is a valuable tool for research involving PCP4, a protein involved in regulating neuronal development and function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot analysis. By binding to the PCP4 protein, this antibody allows for the detection and analysis of PCP4 in different cell types, making it an ideal choice for studies in neuroscience and related fields.PCP4 is known for its role in modulating calcium signaling and synaptic plasticity, making it a key player in processes such as learning and memory.
Dysfunction of PCP4 has been implicated in various neurological disorders, making it a promising target for further research aimed at understanding and potentially treating conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia. By studying the function of PCP4, researchers may uncover valuable insights into the underlying mechanisms of these disorders and discover new therapeutic strategies.
Antibody Name:
PCP4 Antibody (PACO13791)
Antibody SKU:
PACO13791
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:5-1:20
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human PCP4
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO13791(PCP4 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as AlzheimerÂ’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.
Synonyms:
purkinje cell protein 4
UniProt Protein Function:
PCP4: Probable regulator of calmodulin signaling. Belongs to the PCP4 family.Protein type: Cell development/differentiation; Calcium-bindingChromosomal Location of Human Ortholog: 21q22.2Cellular Component: cytosol; nucleusMolecular Function: calmodulin bindingBiological Process: central nervous system development
