The Phospho-PDE4B/PDE4C/PDE4D (S133/119/190) Antibody (PACO06016) is a valuable research tool for investigating the phosphorylation status of phosphodiesterase 4 (PDE4) isoforms in various cellular processes. This polyclonal antibody, produced in rabbits, is highly specific to phosphorylated forms of PDE4B, PDE4C, and PDE4D at serine residues 133, 119, and 190, respectively.PDE4 enzymes play a critical role in regulating intracellular levels of cyclic adenosine monophosphate (cAMP) and are involved in various signaling pathways that control immune response, cell proliferation, and neurotransmission. Phosphorylation of PDE4 isoforms at specific sites can modulate their enzymatic activity and localization, impacting downstream cellular functions.
Validated for use in Western blot applications, this antibody allows for the detection and quantification of phosphorylated PDE4B, PDE4C, and PDE4D in cell lysates, providing insights into the signaling events associated with cAMP regulation. Its ability to specifically target these phosphorylated isoforms makes it an essential tool for studies in cell biology, pharmacology, and neuroscience, offering researchers a deeper understanding of the complex regulatory mechanisms involving PDE4 enzymes.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
NCBI Summary:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
