The PRSS50 Polyclonal Antibody (PAC020775) is a valuable tool for researchers studying PRSS50, a serine protease implicated in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for Western blotting applications. By targeting the PRSS50 protein, this antibody allows for the detection and analysis of PRSS50 in different cell types, making it ideal for investigations in developmental biology and reproductive health.PRSS50, also known as testisin, plays a critical role in sperm function and male fertility by promoting sperm motility and fertilization.
Its involvement in these processes makes it a key target for studies on infertility and reproductive disorders. Furthermore, the dysregulation of PRSS50 has been linked to certain cancers and neurological diseases, highlighting its significance in various pathological conditions. Understanding the functions of PRSS50 is essential for developing potential therapeutic interventions in these areas.
Antibody Name:
PRSS50 Antibody (PACO20775)
Antibody SKU:
PACO20775
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PRSS50
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20775(PRSS50 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
May be involved in proteolysis through its threonine endopeptidase activity. Testis specific. Differentially expressed in some breast cancer tissues.
Synonyms:
protease, serine, 50
UniProt Protein Function:
TSP50: May be involved in proteolysis through its threonine endopeptidase activity. Belongs to the peptidase S1 family.Protein type: EC 3.4.25.-; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 3p21.31Cellular Component: endoplasmic reticulum; cytoplasmMolecular Function: threonine endopeptidase activity; serine-type endopeptidase activityBiological Process: proteolysis
