The PSG3 Polyclonal Antibody (PAC035478) is a crucial tool for researchers studying PSG3, a member of the pregnancy-specific glycoprotein family involved in immune regulation during pregnancy. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the PSG3 protein, researchers can accurately detect and study its expression in various cell types, providing valuable insights into immunological processes related to pregnancy and reproductive health.PSG3, also known as pregnancy-specific beta-1-glycoprotein 3, plays a vital role in modulating immune responses to establish immune tolerance towards the fetus during pregnancy.
Its unique function in pregnancy-related immune regulation makes it a promising target for investigating reproductive disorders and complications. Research on PSG3's involvement in immune modulation can lead to the development of novel diagnostics and therapeutic strategies for pregnancy-related complications and disorders.In summary, the PSG3 Polyclonal Antibody (PAC035478) offers researchers a reliable tool for investigating the role of PSG3 in immune regulation during pregnancy and reproductive health. With its high specificity and sensitivity, this antibody is instrumental in advancing our understanding of pregnancy-related immune processes and exploring potential therapeutic interventions.
Western blot. All lanes: PSG3 antibody at 10µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO35478 at dilution of 1:100.
The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
