The PTPN20A Polyclonal Antibody (PACO20293) is a valuable tool for researchers studying PTPN20A, a protein tyrosine phosphatase implicated in various cellular processes, including cell signaling and metabolism. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blotting applications. By targeting the PTPN20A protein, this antibody allows for the detection and analysis of PTPN20A expression in a variety of cell types, making it an ideal choice for investigations in molecular biology and disease research.
PTPN20A, also known as protein tyrosine phosphatase N20, plays a critical role in regulating signal transduction pathways by dephosphorylating target proteins. Its involvement in key cellular functions makes it a promising target for studies on cancer, metabolic disorders, and other diseases. Understanding the function of PTPN20A is essential for developing targeted therapies that modulate its activity and impact disease progression.
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20293(PTPN20B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-2: K562 cells, human testis tissue, Primary antibody: PACO20293(PTPN20B Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20293(PTPN20B Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants.
Synonyms:
protein tyrosine phosphatase, non-receptor type 20B
UniProt Protein Function:
Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
