Description
SEMA3G Antibody (PACO14973)
The SEMA3G Polyclonal Antibody (PAC014973) is a valuable tool for researchers studying SEMA3G, a protein involved in immune regulation and cancer development. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the SEMA3G protein, this antibody enables detection and analysis in various cell types, making it suitable for investigations in immunology and oncology research.SEMA3G is a member of the semaphorin family, known for its role in axon guidance and immune regulation. Recent studies have identified SEMA3G as a key player in cancer progression, with implications for tumor growth and metastasis.
Understanding the function of SEMA3G in the immune system and its impact on cancer biology is essential for the development of targeted therapies and personalized medicine approaches.Overall, the SEMA3G Polyclonal Antibody offers researchers a reliable tool for studying the role of SEMA3G in immune regulation and cancer development. Its specificity and sensitivity make it a valuable asset in the quest for new insights and potential treatments in these critical areas of research.
| Antibody Name: | SEMA3G Antibody (PACO14973) |
| Antibody SKU: | PACO14973 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:5000, WB:1:200-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human SEMA3G |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 50 μg, Lane: Jurkat cells, Primary antibody: PACO14973(SEMA3G Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 minutes. |
| Background: | Semaphorins are a class of secreted and membrane proteins that act as axonal growth cone guidance molecules. They primarily act as short-range inhibitory signals and signal through multimeric receptor complexes. They are usually cues to deflect axons from inappropriate regions, especially important in neural system development. The major class of proteins that act as their receptors are called plexins.SEMA3G possesses anti-migration and anti-invasion ability. SEMA3G inhibited tumor cell migration and invasion, which may be obtained through cell autonomous or paracrine mechanisms, and SEMA3G is a potential target for antitumor migration and invasion. |
| Synonyms: | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G |
| UniProt Protein Function: | SEMA3G: a secreted protein that has chemorepulsive activities for sympathetic axons. A high-affinity ligand of NRP2. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p21.1 Cellular Component: membrane Molecular Function:receptor activity Biological Process: multicellular organismal development |
| NCBI Summary: | The transcription of this gene is activated by PPAR-gamma, and the resulting protein product plays a role in endothelial cell migration. Expression of this gene also inhibits tumor cell migration and invasion. [provided by RefSeq, Jul 2016] |
| UniProt Code: | Q9NS98 |
| NCBI GenInfo Identifier: | 74761676 |
| NCBI Gene ID: | 56920 |
| NCBI Accession: | Q9NS98.1 |
| UniProt Related Accession: | Q9NS98 |
| Molecular Weight: | |
| NCBI Full Name: | Semaphorin-3G |
| NCBI Synonym Full Names: | semaphorin 3G |
| NCBI Official Symbol: | SEMA3GÂ Â |
| NCBI Official Synonym Symbols: | sem2Â Â |
| NCBI Protein Information: | semaphorin-3G |
| UniProt Protein Name: | Semaphorin-3G |
| UniProt Synonym Protein Names: | Semaphorin sem2 |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA3GÂ Â |
| UniProt Entry Name: | SEM3G_HUMAN |
