The TRA2A Polyclonal Antibody (PAC023749) is a vital tool for researchers investigating TRA2A, an essential splicing factor involved in the regulation of gene expression. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the TRA2A protein, researchers can accurately detect and analyze its expression in various cell types, making it an excellent choice for studies in molecular biology and disease research.
TRA2A is a well-known regulator of alternative splicing, playing a crucial role in controlling the production of different mRNA isoforms. Dysregulation of TRA2A has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in cellular function and disease progression. By exploring the function of TRA2A, researchers can gain valuable insights into disease mechanisms and potential therapeutic targets.
Synthesized peptide derived from internal of human TRA-2 alpha .
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HUVEC cells, using TRA-2alpha antibody.
Immunofluorescence analysis of HeLa cells, using TRA-2 alpha antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using TRA-2 alpha antibody.
Background:
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing.
Synonyms:
Transformer-2 protein homolog; TRA-2 alpha;
UniProt Protein Function:
TRA2A: Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Belongs to the splicing factor SR family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:RNA processing; RNA splicing; RNA-binding
Biological Process: nuclear mRNA splicing, via spliceosome
NCBI Summary:
This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
