The Tri-Methyl Histone H2B Lys43 Polyclonal Antibody (PACO00149) is a valuable tool for researchers studying epigenetics and chromatin modifications. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot and immunofluorescence applications.Histone modifications play a crucial role in gene regulation and chromatin structure, and tri-methylation of histone H2B at lysine 43 is associated with transcriptional activation. The Tri-Methyl Histone H2B Lys43 antibody allows for the detection and analysis of this specific histone modification in various cell types, providing insights into gene expression patterns and regulatory mechanisms.
Research on histone modifications is essential for understanding the epigenetic regulation of gene expression, cell differentiation, and development. The Tri-Methyl Histone H2B Lys43 antibody is a valuable tool for investigating the role of histone modifications in various biological processes and diseases, including cancer, developmental disorders, and neurodegenerative diseases. Its specificity and reliability make it a valuable asset for epigenetics research.
Antibody Name:
Tri-Methyl-Histone H2B (Lys43) Antibody
Antibody SKU:
PACO00149
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:1000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthetic Peptide
Form:
Liquid
Storage Buffer:
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
H2B1A: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm. Belongs to the histone H2B family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 6p22.2Cellular Component: extrinsic to plasma membrane; nuclear chromosome, telomeric region; nucleoplasm; nucleosome; nucleusMolecular Function: DNA binding; protein heterodimerization activityBiological Process: establishment and/or maintenance of chromatin architecture; inflammatory response; nucleosome assembly; nucleosome disassembly; plasminogen activation; positive regulation of binding; spermatogenesis, exchange of chromosomal proteins
UniProt Protein Details:
NCBI Summary:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]
