The USP45 Monoclonal Antibody (PAC017402) is a cutting-edge tool for researchers studying USP45, a key protein involved in cell signaling and protein degradation pathways. This antibody is produced using state-of-the-art techniques and has been rigorously tested to ensure its specificity and sensitivity in a variety of experimental applications.USP45 is a deubiquitinating enzyme that plays a critical role in the regulation of protein turnover and cellular processes. Dysregulation of USP45 has been linked to various diseases, including cancer, neurodegenerative disorders, and autoimmune conditions. By using the USP45 Monoclonal Antibody, researchers can investigate the function and activity of USP45 in both normal and disease states, providing valuable insights into potential therapeutic targets and treatment strategies.
With its high specificity and reliability, the USP45 Monoclonal Antibody (PAC017402) is an essential tool for scientists working in the fields of cell biology, molecular biology, and drug discovery. Its versatility and performance make it an invaluable asset for research projects aiming to unravel the complexities of USP45-mediated signaling pathways and their impact on human health.
Antibody Name:
USP45 Antibody (PACO17402)
Antibody SKU:
PACO17402
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PACO17402(USP45 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17402(USP45 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. A wide range of enzymes facilitate the proteolytic Ub pathway, including USPs (ubiquitin specific peptidases), which are cysteine proteases that are responsible for the release of ubiquitin from a ubiquitylated substrate and precursor fusion proteins. USP45 (Ubiquitin carboxyl-terminal hydrolase 45), also known as Deubiquitinating enzyme 45, is a 819 amino acid, protein that is involved in ubiquitin-dependent protein catabolism. USP45 differs from other USPs in that it contains a UBP-type zinc finger, a domain which binds ubiquitin. Although USP45 is broadly expressed, the highest levels can be found in skeletal muscle, spleen and ovary. There are three isoforms of USP45 which are produced as a result of alternative splicing.
Synonyms:
ubiquitin specific peptidase 45
UniProt Protein Function:
USP45: Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:EC 3.4.19.12; Ubiquitin-specific protease; Protease; Ubiquitin conjugating system
