The VWA5A Antibody (PAC015860) is a powerful tool for researchers studying the VWA5A protein, which plays a role in various cellular processes. This antibody, produced through rabbit immunization, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the VWA5A protein, this antibody allows for the detection and analysis of VWA5A expression in different cell types, making it an essential tool for investigations in cell biology and disease research.VWA5A, also known as Von Willebrand factor A domain-containing protein 5A, is involved in cell adhesion, signal transduction, and protein-protein interactions.
Its function in these processes implicates it in various diseases, including cancer and neurological disorders. By studying the role of VWA5A, researchers can gain insights into disease mechanisms and potentially identify new therapeutic targets for treatment.Overall, the VWA5A Antibody offers a reliable and specific tool for researchers seeking to explore the functions and implications of the VWA5A protein in health and disease.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15860(VWA5A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Human Adrenal pheochromocytoma tissue, Jurkat cells, A549 cells, Primary antibody: PACO15860(VWA5A Antibody) at dilution 1/275, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15860(VWA5A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid, protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
Synonyms:
von Willebrand factor A domain containing 5A
UniProt Protein Function:
VWA5A: May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in, may contribute directly to or modify tumorigenesis. 4 isoforms of the human protein are produced by alternative splicing.
von Willebrand factor A domain-containing protein 5A
NCBI Synonym Full Names:
von Willebrand factor A domain containing 5A
NCBI Official Symbol:
VWA5AÂ Â
NCBI Official Synonym Symbols:
BCSC1; BCSC-1; LOH11CR2AÂ Â
NCBI Protein Information:
von Willebrand factor A domain-containing protein 5A; breast cancer suppressor candidate 1; loss of heterozygosity 11 chromosomal region 2 gene A protein; loss of heterozygosity, 11, chromosomal region 2, gene A; ortholog of mouse AW551984
UniProt Protein Name:
von Willebrand factor A domain-containing protein 5A
UniProt Synonym Protein Names:
Breast cancer suppressor candidate 1; BCSC-1; Loss of heterozygosity 11 chromosomal region 2 gene A protein
