The Phospho-IRS1 (S636) Polyclonal Antibody (CABP0225) is a valuable tool for researchers studying insulin receptor substrate 1 (IRS1) phosphorylation at serine 636. This antibody, produced in rabbits, is highly specific for detecting phosphorylated IRS1 at this site in human samples and is validated for use in Western blot applications. By targeting this specific phosphorylation site, researchers can gain insights into the regulation of IRS1 signaling pathways in various cell types.IRS1 is a key player in insulin signaling, controlling glucose and lipid metabolism in the body. Phosphorylation of IRS1 at serine 636 has been implicated in insulin resistance, a condition associated with type 2 diabetes and other metabolic disorders.
Studying the phosphorylation of IRS1 at this site can provide valuable information for understanding the molecular mechanisms underlying insulin resistance and developing targeted therapies for related diseases.With its high specificity and validated performance in Western blotting, the Phospho-IRS1 (S636) Polyclonal Antibody (CABP0225) is a reliable tool for researchers investigating IRS1 phosphorylation and its role in insulin signaling pathways. Its applications extend to studies in diabetes, obesity, and other metabolic diseases where IRS1 dysregulation plays a critical role.
Product Name:
Phospho-IRS1-S636 Rabbit Polyclonal Antibody
SKU:
CABP0225
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A phospho specific peptide corresponding to residues surrounding S636 of human IRS1
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Purification Method:
Affinity purification
Gene ID:
3667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 3T3 cells, using Phospho-IRS1-S636 Rabbit pAb (CABP0225).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
