10392 results for 'p38 black make'

The p38 MAPK signaling pathway is an intracellular signaling pathway that plays a crucial role in cellular responses to various stressors and inflammatory stimuli. It is a part of the larger MAPK ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

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Fenofibrate, also known as FEN, is a drug that is used to lower cholesterol levels. It works by blocking the absorption of dietary cholesterol in the small intestine and therefore, re ...

The Mitogen-Activated Protein Kinase (MAPK) pathway is a pivotal signaling cascade that plays a crucial role in mediating cellular responses to various external stimuli. This pathway is intricate ...

Introduction to MAPK Signaling in Cellular Processes Mitogen-Activated Protein Kinase (MAPK) signaling pathways are crucial in transmitting signals from the cell surface to the DNA in the c ...

Nod-like receptors Nod like receptors (NLRs) are a versatile family of relatively recently discovered intracellular receptors which have a b ...

Chemokines are small signaling proteins that play a crucial role in the immune system by directing the movement of cells, orchestrating immune responses, and maintaining tissue homeostasis. Th ...

Delving into TNF alpha's critical role in inflammation and its therapeutic targeting. Key Takeaways: TNF alpha is a crucial cytokine in inflammation and apoptosis. Its structure facilita ...

What is VEGF? Vascular Endothelial Growth Factors (VEGFs) are a group of homodimeric polypeptides, and are master regulators of vascular development, maintenance and ...

Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

During my PhD I knew how networking was important, it helped me source reagents off other labs, get the best advice and helped me land a post doc at Cambridge University. Its not ...

Science communication (Scicomm) is currently on the up. As rebellion against the increasing distrust of science stemmed from bigoted and ignorant leaders, scientists are turning to ...

ST2, a member of the IL-1R Subfamily ST2 is a member of the IL-1R subfamily and was identified in 1989 [1]. The ST2 gene is located on chromos ...

What is Necrosis? Necrosis is a pathological process characterized by the death of cells or tissues within a living organism. It occurs as a result of various factors, including injury, inf ...

HMGB1 Functional Overview High mobility group box 1 ( HMGB1), a member of the high-mobility group (HMG) family, was first identified in the thymus in 1973 a ...

Imagine a highly trained soldier, elite and effective, sent to the front lines of a relentless war. Day after day, they fight without rest, their supplies dwindle, and the enemy never stops coming. E ...

BRIEF HISTORY OF THE “GREEN” EVOLUTION OF OXYGEN AND CARBON DIOXIDE WITHIN OUR ATMOSPHERE Million years ago carbon dioxide (CO2) levels used to be consid ...

Melanoma is an aggressive type of skin cancer that originates in melanocytes, the cells responsible for producing melanin, which gives skin its color. Although it is less common than oth ...

Transmission of SARS-CoV-2 (COVID-19) via Droplets and Aerosols What is COVID-19? COVID-19, the dise ...

The Spanish flu pandemic of 1918-1919 was the deadliest in history. It is estimated that up to 100 million people died from the virus, which is more than three times the number who ...

Rapid Antibody & Antigen tests available from Assay Genie ...

3D Organoid Cell Viability Assay (AKES081) effectively measures BENO model viability across different storage conditions. AKES081 detects significant viability differences, particularly ...

Like needles in a haystack, interesting speakers that bring charisma and rock n roll to their talks are hard to come by. No matter what the research interests of the audience, these speakers h ...

Quick Facts About TezepelumabWhat is Tezepelumab?Tezepelumab is a monoclonal antibody designed to inhibit thymic stromal lymphopoietin (TSLP), a key driver of airway inflammation in sev ...

A neuron is a cell that processes and transmits information through electrical and chemical signals. There are trillions of them in the human brain, which is able to carry out so many comple ...

Quick Facts About TidutamabWhat is Tidutamab?Tidutamab is a monoclonal antibody designed to target somatostatin receptor 2 (SSTR2), a key protein involved in various neuroendocrine tumo ...

What You Need to Know About LusvertikimabWhat is Lusvertikimab?Lusvertikimab is a monoclonal antibody designed to inhibit the IL-4 receptor, a key player in regulating immune responses, ...

Making the switch! This article provides some help on CV writing tips for scientists for PhDs and PostDocs looking for jobs outside of academia and what they might need to ...

Millions of people are afflicted with cancer each year. 2016 statistics for the USA alone show over half a million deaths attributed to cancer 1. We have come a long way from our early unders ...

The choice of appropriate cell culture supplements emerges as a crucial factor in ensuring the efficacy and consistency of experimental results. Among the various options available, two common ...

What You Need to Know About BersanlimabWhat is Bersanlimab?Bersanlimab is a cutting-edge anti-CD47 monoclonal antibody designed to disrupt cancer cells' evasion of immune detection.What ...

Objectives & Key Results Objectives & Key Results (OKRs) is a framework for setting and tracking goals. At Assay Genie, we've tailored this approach to sui ...

Glucagon-like peptide-1 (GLP-1) is a critical hormone in the regulation of glucose metabolism and has garnered significant attention due to its therapeutic potential in managing diabetes ...

Quick Facts About EnavatuzumabWhat is Enavatuzumab?Enavatuzumab is a monoclonal antibody targeting the TWEAK receptor (Fn14), pivotal in tumor growth and immune regulation.What is the m ...

What You Need to Know About AmatuximabIs Amatuximab safe?Amatuximab has shown a manageable safety profile in clinical trials, with most side effects being mild to moderate. Severe adver ...

Pyroptosis is an immunogenic form of cell death, meaning that it triggers an immune response. This makes pyroptosis a potentially promising target for immunotherapies that aim to bo ...

Assay Genie attended AACR 2025 in ChicagoSean, Shane and David had a great few days in Chicago discussing research with scientists from across the globe at the Assay Genie booth. " ...

Quick Facts About MonalizumabWhat is Monalizumab?Monalizumab is a first-in-class immune checkpoint inhibitor targeting NKG2A, developed to enhance anti-tumor immune response by blocking ...

What You Need to Know About CodrituzumabWhat is Codrituzumab?Codrituzumab is an investigational monoclonal antibody targeting CD47, an immune checkpoint that regulates immune responses ...

The 3D Organoid Cell Viability Assay (AKES081) demonstrated high sensitivity and low cytotoxicity, making it ideal for long incubation studies (24-48 hours) and high-throughput applicat ...

Quick Facts About TigatuzumabWhat is Tigatuzumab?Tigatuzumab is a monoclonal antibody that targets the death receptor 5 (DR5) pathway, inducing apoptosis in cancer cells.What is the mec ...

Mesenchymal stem cells (MSCs) have emerged as pivotal players in the realm of regenerative medicine due to their unique properties and versatile potential. Originally discovered in the bone marro ...

Quick Facts About IcrucumabWhat is Icrucumab?Icrucumab is a monoclonal antibody that targets vascular endothelial growth factor receptor-1 (VEGFR-1) to inhibit tumor angiogenesis.How Do ...

What You Need to Know About DenosumabWhat is Denosumab?Denosumab is a monoclonal antibody used primarily to treat osteoporosis and bone-related complications in cancer patients. It targ ...

How to increase lab productivityWhen you look back at some weeks in the lab it seems like you have achieved nothing and your lab productivity can be low. Your cloning hasn’t worked or your mice ...

At ELISA Genie we are hugely interested in the future of science and we feel that PhD students are at the heart of this. Our new series, #LabChats, will see us interview different scient ...

Mouse monoclonal antibodies are a valuable tool in the biomedical field. They can be used for a variety of applications, from research to clinical diagnostics. In this blog post, we ...

Quick Facts About UtomilumabWhat is Utomilumab?Utomilumab is a monoclonal antibody targeting 4-1BB (CD137), a co-stimulatory receptor on T-cells, designed to enhance anti-tumor immunity ...

PhD Interview Presentation Dos and Don’ts It is becoming increasingly common for master's and undergraduate students to present data they produced during their rese ...

Quick Facts About GirentuximabWhat is Girentuximab?Girentuximab is a monoclonal antibody targeting carbonic anhydrase IX (CAIX), predominantly expressed in renal cell carcinoma (RCC) ce ...

RIPA (Radio Immuno Precipitation Assay) buffer is mostly used when carrying out a western blot or immunoprecipatation assay. A RIPA buffer is used in order to lyse cells and extract protein fr ...

Introduction to SLAMF7 in Cancer Immunotherapy SLAMF7, also known as Signaling Lymphocytic Activation Molecule F7, is a surface receptor found on natural killer (NK) cells, T cells, ...

The Assay Genie 3D Organoid Cell Viability Assay (AKES081) provided superior results compared to ThermoScientific PrestoBlue, maintaining over 100% viability at all time points in untre ...

Quick Facts About NaratuximabWhat is Naratuximab?Naratuximab is an anti-CD37 monoclonal antibody-drug conjugate (ADC) designed to target B-cell malignancies, particularly non-Hodgkin ly ...

Quick Facts About BelimumabWhat is Belimumab?Belimumab is a monoclonal antibody used to treat systemic lupus erythematosus (SLE), an autoimmune disease. It is marketed under the brand n ...

In the realm of biological and biochemical research, solutions play a pivotal role in various experimental procedures, from cell culture to molecular biology assays. Among the plethora ...

Quick Facts About ZilovertamabWhat is Zilovertamab?Zilovertamab is a monoclonal antibody targeting ROR1, a receptor tyrosine kinase overexpressed in hematologic cancers and solid tumors ...

Quick Facts About TarextumabWhat is Tarextumab?Tarextumab is a novel therapeutic antibody designed to target the Notch signaling pathway, which plays a crucial role in tumor progression ...

Understanding the Role of APOE in Neurodegenerative DiseasesRecent findings reveal that a specific gene variant, APOE, significantly increases the risk of Alzheimer's and Parkinson's diseases, highli ...

Quick Facts About EnapotamabWhat is Enapotamab?Enapotamab is an experimental antibody-drug conjugate (ADC) developed to target tumor cells selectively, offering new hope in cancer treat ...

Sepsis, a life-threatening condition, is characterized by a dysregulated immun ...

The use of M2 Supplement in organoid culture has revolutionized the way researchers cultivate and maintain these three-dimensional (3D) cellular models. Organoids—self-organizing cell cl ...

Histamine, a biogenic amine, plays a crucial role in various physiological processes, including immune responses, gastric acid secretion, and neurotransmission. Central to the action of histamine ...

In the realm of biological and biochemical research, solutions play a pivotal role in various experimental procedures, from cell culture to molecular biology assays. Among the plethora of solu ...

What Are Personalized Cancer Vaccines? Personalized cancer vaccines are a cutting-edge approach in cancer treatment that are designed to activate a patient's immune s ...

Over the past few years momentum has gained in the scientific publishing community for researchers to publish their data in open access scientific journals. Open access to published research o ...

Quick Facts About BegelomabWhat is Begelomab?Begelomab is a monoclonal antibody that targets CD26, a key molecule involved in immune regulation. It has been studied for its potential ap ...

Quick Facts About AvdoralimabWhat is Avdoralimab?Avdoralimab is a monoclonal antibody targeting C5aR1, playing a crucial role in modulating immune response and inflammation.What is the ...

Key Facts About SacituzumabWhat is Sacituzumab?Sacituzumab is an antibody-drug conjugate (ADC) that targets the tumor-associated antigen Trop-2, used to treat various cancers, including ...

Quick Facts About RagifilimabWhat is Ragifilimab?Ragifilimab is an investigational anti-CD47 monoclonal antibody developed to block the CD47-SIRPα interaction, thereby enhancing macroph ...

Quick Info Section: Key Facts About CevostamabWhat is Cevostamab?Cevostamab is an investigational monoclonal antibody targeting CD47, a cell surface protein that helps cancer cells evad ...

By Dr. Niclas Thomas “Data science” is a recent addition to the vocabulary of analytics, and can mean many different things to different people. As f ...

Quick Facts About ElotuzumabWhat is Elotuzumab?Elotuzumab is a monoclonal antibody designed to enhance the immune system's ability to detect and destroy multiple myeloma cells. It targe ...

What are Stem Cells? Stem cells are primitive, undifferentiated, and unspecialised cells that are found in multicellular organism ...

In the intricate world of cancer biology, a silent conversation is constantly unfolding between tumor cells and their environment. For decades, we viewed this dialogue as a one-way street, with cance ...

What You Need to Know About VorsetuzumabWhat is Vorsetuzumab?Vorsetuzumab is a monoclonal antibody targeting CD70, a protein found in various cancers. It shows promise for advancing can ...

For decades, the fight against cancer has been a grueling battle of attrition, with treatments often as harsh as the disease itself. But a revolutionary approach, chimeric antigen receptor (CAR)-T ce ...

Quick Info Section: Key Facts About PlozalizumabWhat is Plozalizumab?Plozalizumab is an investigational monoclonal antibody that targets CD47, a key immune checkpoint in cancer cells. B ...

Quick Facts About VixarelimabWhat is Vixarelimab?Vixarelimab is an investigational monoclonal antibody developed to target oncostatin M receptor beta (OSMRβ), a key pathway involved in ...

Key Facts About TalacotuzumabWhat is Talacotuzumab?Talacotuzumab is a monoclonal antibody designed to target CD123, a protein commonly found on the surface of certain blood cancer cells ...

Quick Facts About ErenumabWhat is Erenumab?Erenumab is a fully human monoclonal antibody designed to prevent migraines by targeting the calcitonin gene-related peptide (CGRP) receptor.

For decades, the primary strategy in cancer treatment has been to trigger apoptosis, a form of programmed cell death, in malignant cells. However, many cancers develop resistance to apoptosis-induci ...

The Dynex DS2 platform fully automates the MR-proANP and MR-proADM ELISA assays, streamlining sample processing from loading to detection. Automation ensures consistent assay performanc ...

Quick Facts About SiltuximabWhat is Siltuximab?Siltuximab is a monoclonal antibody targeting interleukin-6 (IL-6), a cytokine involved in inflammation and immune regulation.What is the ...

What You Need to Know About IfabotuzumabWhat is Ifabotuzumab?Ifabotuzumab is a monoclonal antibody targeting EphA3, a receptor tyrosine kinase overexpressed in certain cancers. It plays ...

Explore 29 essential tips for crafting a compelling and well-structured PhD thesis, blending effective writing practices with time management and academic rigor for a successful dissertation jour ...

Introduction to CD80 and Its Role in Immune Activation CD80 is a critical immune checkpoint molecule that plays an essential role in T cell activation through co-stimulatory pathway ...

Key Facts About EtigilimabWhat is Etigilimab?Etigilimab is an anti-TIGIT monoclonal antibody being studied for its potential role in cancer immunotherapy.What role does Etigilimab play ...

Nanosilver is the most commercialised nanoparticle routinely used for its antibacterial purposes in food preservation, cosmetic and health products such as medical devices and wound treatme ...

Why do powerful cancer immunotherapies work wonders for some patients but fail for others? The answer may lie not just in the cancer cells themselves, but in the energy levels of our own immune warri ...

Phosphorylation ELISA Screen cell lysates without Western Blot analysis! Determine phosphorylated protein to verify pathway activation! ...

Cell-Based ELISA Kits No More Western Blots! Over 1,600 Cell-Based ELISA kits to measure the relative levels of intracellular and phosphorylat ...

ELISA Sampler Packs Based on thousands of citations and years of scientific endeavour, Assay Genie has developed ELISA Sampler Packs. An ELISA Sampler Pack is a ...

Product CitationsMore than 1,000 cited products in scientific journalsWe're not just any scientific company; our products have made waves in the scientific community. From groundbreakin ...

Flow Cytometry Antibodies Validated Antibodies for Flow Cytometry! Explore FC Antibodies window.SHOGUN_IMAGE_ELEMENTS = window.SHOGUN_IMAG ...

What is IHC? Immunohistochemistry (IHC) is a valuable tool used for the identification of specific antigens within embedded tissue prepara ...

Cell Viability, Cytotoxicity & Proliferation AssaysExplore AssaysJump to:- Cell Viability Assays- Cell Cytotoxicity Assays- Cell Proliferation Assayscheck_box   Fast-DeliveryDe ...

Key Takeaways: Site-directed mutagenesis (SDM) enables precise DNA sequence alterations. Used for investigating protein activity changes and introducing beneficial mutations. GenieClone ki ...

What is RIPA Buffer? RIPA (Radio Immuno Precipitation Assay) buffer is primarily used when conducting a western blot or immunoprecipatation assay. A RIPA buffer is used in order to l ...