10182 results for 'best ii'

What are MHC Class I molecules? The MHC class I is a glycoprotein that is expressed on all nucleated cells of the human body. MHC class I are important in disease defense against viruses, b ...

Major Histocompatibility Complex (MHC) molecules are essential for immune recognition and response. They are specialized glycoproteins that present antigens to T cells, allowing the immu ...

کیت سنجش فعالیت آنزیم تبدیل آنژیوتانسین II (ACE2) (فلورومتریک) آنزیم مبدل آنژیوتانسین II ، (ACE2, EC 3.4.17.23) یک متالوپروتا ...

کیت غربالگری مهار کننده آنزیم آنژیوتانسین II (ACE2) آنزیم تبدیل آنژیوتانسین II(ACE2, EC 3.4.17.23)، کربوکسی پپتیداز بخشی از س ...

Cell culture techniques are fundamental to biomedical research, providing crucial insights into cellular functions, drug discovery, and disease mechanisms. A critical step in cell culture is the ...

Boiling proteins is a critical step in preparing samples for Western blotting, a technique widely used to detect specific proteins in complex mixtures. Proper heating denatures the prote ...

血管紧张素转换酶II（ACE2）活性测定试剂盒（荧光） 血管紧张素转换酶II（ACE2）活性测定试剂盒（荧光） 血管紧张素转化酶II（ACE2，EC 3.4.17.23）是一种基 ...

The angiotensin pathway is a pivotal hormonal system that plays a crucial role in regulating blood pressure and maintaining fluid and electrolyte balance within the body. This complex biochemical ...

Lymphocyte Activation Gene-3 (LAG-3) is an immune checkpoint receptor that plays a critical role in regulating T cell function. In recent years, LAG-3 has emerged as a potential target f ...

Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell survival and ...

What is COVID-19 COVID-19, the disease caused by the coronavirus named SARS-CoV-2, first identified in Wuhan, China in December 2019 has spr ...

Platinum based cancer drugs Despite nearly 50% of all anti-cancer treatments being platinum-based, there is an urgent need to develop novel therapeutics ...

Interferons are key cytokines in the immune system, crucial for combating viral and bacterial infections, with significant roles in both innate and adaptive immunity responses. Key Takeaways ...

The flu is a highly contagious virus that affects the respiratory system. It can cause fever, muscle aches, and coughing. In some cases, it can lead to more serious health complicat ...

Bone Morphogenetic Proteins (BMP) were first discovered in the 1960s by Dr.Marshall Urist, an orthopaedic surgeon at UCLA (Urist 1965). BMPs are classically associated with their roles in limb ...

Microglial Functions Explained: Immunity, Inflammation & NeurodegenerationKey TakewaysMicroglia are immune cells in the CNS, originating from myeloid precursor cells.They surveil th ...

Kit di Estrazione DNA/RNA Virus Il Kit di Estrazione dell'Acido Nucleico Virale II è stato progettato specificamente per la purificazione efficiente del DNA virale e dell'RNA vir ...

Structure, Function, and Detection Assays for COVID-2019 Background The global spread of the novel co ...

Key Takeaways: Microglia are immune cells in the CNS, originating from myeloid precursor cells. They surveil the CNS, respond to changes, and maintain neural health. Microglia exist in dif ...

Parkinson's disease (PD) is a progressive neurological disorder that predominantly affects the motor system, leading to a wide range of symptoms including tremors, rigidity, bradykinesia (slowne ...

Exploring the multifaceted role of dendritic cells in immune function and disease. Key Takeaways DCs are professional antigen-presenting cells that capture, process, and pres ...

Glutamate receptors are pivotal in mediating excitatory neurotransmission in the central nervous system (CNS), playing crucial roles in synaptic transmission, plasticity, learning, and memory. Th ...

The intricate process of mesenchymal stem cell (MSC) differentiation is a cornerstone of developmental biology and regenerative medicine. Mesenchymal stem cells, renowned for their self-renewal c ...

By Sonika Singh PhD candidate, University of Nottingham A Devastating Disease Multiple Sclerosis (MS) is a chronic and inflammatory disease ba ...

TIGIT (T cell immunoreceptor with Ig and ITIM domains) has emerged as a promising target in cancer immunotherapy and the treatment of autoimmune diseases. As a checkpoint receptor, TIGIT ...

Growth factors play a vital role in the complex web of biological processes, serving as key regulators in various essential events. They exert significant influence over cruc ...

Introduction Discover the multifaceted role of CD33, a critical player in immune function and disease, shaping our approach to treating cancers and neurodegenerative condition ...

Non-Small Cell Lung Carcinoma (NSCLC) is the most common type of lung cancer, representing about 85% of all lung cancer cases. NSCLC includes several subtypes, with distinct biological c ...

CD4+ T cells are central to the immune system, functioning as coordinators of immune responses and regulators of immune tolerance. These cells are divided into two primary subtypes: Help ...

What You Need to Know About MilatuzumabWhat is Milatuzumab?Milatuzumab is a humanized monoclonal antibody targeting CD74, a molecule involved in antigen presentation and cell signaling.

In the intricate landscape of cellular communication, lies a sophisticated ...

Overview of Diabetes Mellitus Diabetes mellitus (DM) is a major epidemic that affects over 347 million people worldwide (Danaei et al. 2011). The World He ...

In 2006, upon completion of the Human Genome Project, it was discovered that nearly 8% of the human genome is made up of viral DNA. These viral remnants are composed of ancient germ ...

Autophagy, a fundamental cellular process, is crucial for maintaining cellular homeostasis and responding to various stressors. This self-eating mechanism involves the degradation and recycling o ...

By John Bannon PhD Early Cytokinesis Early cytokinesis; from anaphase to midbody formation cytokinesis is the physical ...

T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is an immune checkpoint receptor that plays a pivotal role in T cell exhaustion, a state where T cells lose their ability to e ...

Cancer immunotherapy has revolutionized treatment options, offering strategies to harness the immune system to target and destroy tumors. One emerging area of interest is the use of OX40 ...

Understanding Lag-3, Tim-3, and TIGIT: Key Players in T Cell RegulationThe immune system's ability to regulate T cell responses is crucial for maintaining homeostasis and combating diseases such as c ...

Immunotherapy has become a central pillar in the fight against cancer, with a focus on enhancing the body’s natural defenses. Among the molecules at the forefront of immunotherapeutic re ...

Articular cartilage, a key player in joint function, owes its unique properties to its extracellular matrix (ECM). This complex, highly specialized structure is not only fundamental in maintainin ...

Alex Lloyd PhD Candidate, Dublin Institute of Technology Did you know that roughly 17.5 million people worldwide die annually from Cardiovascular disease ...

Pancreatic cancer survival rates Despite recent advances in our understanding of this disease, pancreatic cancer is one of the world’s most lethal maligna ...

Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surroundin ...

Blood Coagulation Pathways Blood clotting, also known as hemostasis, is a fascinating and intricate process that ensures our bodies can effectively respond to injuries and prevent excessive ...

As atherosclerosis is a complex inflammatory disease, there are many influential biomarkers that contribute to the disease’s progression as well as biomarkers from atherosclerosis related d ...

Nuclear Factor Erythroid 2–Related Factor 2 (NRF2) orchestrates a principal defense mechanism against oxidative stress and plays a pivotal role in inflammation and disease pathogenesis. This arti ...

The STING (Stimulator of Interferon Genes) pathway plays a pivotal role in the innate immune system's response to cancerous cells and DNA viruses. Exploiting this pathway through STING activators ...

Microglia Astrocytes Oligodendrocytes Glial ...

Melanoma is an aggressive type of skin cancer that originates in melanocytes, the cells responsible for producing melanin, which gives skin its color. Although it is less common than oth ...

Th17 cells, a subset of T helper cells characterized by their production of interleukin-17 (IL-17), play a significant role in the immune system's response to pathogens and in the pathology of a ...

A new way to deliver genetic therapies is making waves in the medical world. The lenti virus vector system has been shown to be more effective than traditional methods of gene thera ...

Quick Facts About ObinutuzumabWhat is Obinutuzumab?Obinutuzumab is a monoclonal antibody targeting CD20, primarily used in treating B-cell malignancies such as chronic lymphocytic leuke ...

Transforming Growth Factor-Beta (TGF-β) signaling pathway plays a pivotal role in orchestrating various cellular processes, ranging from embryonic development to tissue homeostasis and immun ...

What is a Plasma Membrane? The plasma membrane, also known as the cell membrane, is a vital component of all cells. It is a thin, semi-permeable barrier that separat ...

Imagine a battlefield where the enemy doesn't just hide from soldiers—it actively sabotages their weapons. In the tumor microenvironment, cancer cells have evolved a devious strategy: they transfer t ...

Renal Cell Carcinoma (RCC) is the most common form of kidney cancer, originating in the lining of the proximal renal tubules. RCC accounts for approximately 90% of all kidney cancers and ...

Esophageal cancer is a type of cancer that affects the esophagus, which is the tube that carries food and liquids from your mouth to your stomach. Esophageal cancer can cause many d ...

Kinases, key enzymes in cellular signaling, phosphorylate proteins to regulate crucial processes, and their modulation has significant implications in disease treatment. Key Takeaways: K ...

The Brain's Sentinels: How Microglia Shape Neuroinflammation in Disease In the intricate landscape of the human brain, a silent, ever-watchful guardian stands ready to defend against injury and inva ...

Key Points Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a method of gene editing that uses ...

Immune evasion is one of the hallmarks of cancer, where tumor cells employ various strategies to suppress immune responses and prevent destruction by the body’s defense systems. CD200, a ...

Hydroxychloroquine: Potential Treatment for COVID-19 What is Hydroxychloroquine? Hydroxychloroquine (HC ...

One of the greatest challenges in cancer therapy is how tumors evade immune detection. Among the mechanisms cancer cells exploit, the CD47 pathway has emerged as a major player in helpin ...

What is Xeroderma Pigmentosum? Xeroderma pigmentosum (XP) also known De Sanctis-Cacchione syndrome is a rare genetic disorder that affects the skin, eyes and central nervous system. It is c ...

What is Cortisol? Cortisol is a steroid hormone, classified as a member of the glucocorticoid family of hormones. Cortisol is involved in a plethora of physiological processes in order ...

Explore the complexities of Interleukin-10 (IL-10) signaling and regulation, a crucial aspect in immune response modulation and its dual roles in cancer development and therapy. Key Takeaways ...

Quick Facts About LitifilimabWhat is Litifilimab?Litifilimab is a monoclonal antibody developed by Biogen targeting BDCA2, a receptor on plasmacytoid dendritic cells (pDCs), to regulate ...

PVR (Poliovirus receptor), also known as CD155, is a molecule that plays a dual role in regulating the immune response within the tumor microenvironment. While initially discovered as a ...

Blood plasma and serum are essential components of blood and have distinct molecular compositions and uses in the medical and research fields. This article aims to elucidate the differences betwe ...

By Natalia Siomava, PhD Cretinism is a severe medical condition of intellectual disability caused by the deficiency of thyroid hormone (congenital hypothyro ...

Cancer cells are adept at avoiding destruction by the immune system, often exploiting specific pathways to escape detection and elimination. One of these key mechanisms involves the SIRP ...

For decades, we viewed cancer as a rogue army of cells, a biological glitch driven solely by genetic mutations and metabolic greed. We imagined tumors as isolated fortresses, growing in a vacuum of ...

Autophagy, a fundamental cellular process, plays an indispensable role in maintaining cellular homeostasis and ensuring the efficient recycling of cellular components. Through this ...

Quick Facts About FarletuzumabWhat is Farletuzumab?Farletuzumab is a humanized monoclonal antibody targeting folate receptor alpha (FRα), a protein overexpressed in ovarian and other ep ...

Over the past few years I have traversed through academia in a few different guises, first as a PhD student for about 5 years, then onto the traditional route of a post-doc, followed by a sale ...

Quick Facts About TiragolumabWhat is Tiragolumab?Tiragolumab is an anti-TIGIT monoclonal antibody developed to enhance immune responses against cancer cells. It is currently under inves ...

Exploring IL-18: A key cytokine in inflammation and disease. Key Takeaways: IL-18, a pro-inflammatory cytokine, plays a pivotal role in immune responses, particularly in inducing Type II ...

by Ryan Wallis, PhD student, QMUL, Blizard Institute The microscopic world of cell biology was first explored by Robert Hooke in the 17th century and published in his work, Microgr ...

Centrifuges play a pivotal role in scientific research and various industries, enabling efficient separation and isolation of components within a sample. Understanding the relations ...

We know it gets tiring being in the lab every day, especially with the evenings getting darker and gloomier. So, to get you in the festive spirit, we're holding a competition to win money to t ...

Cancer detection often relies on advanced imaging or invasive procedures, frequently catching the disease at later, more challenging stages. Imagine a future where a simple, non-invasive test could ...

Discover the distinct roles of 'In Vivo' and 'In Vitro' in biological research, where one offers a natural context and the other precise control, both vital for scientific advancement.

Novel Gene Therapies for Cystic Fibrosis Cystic Fibrosis Cystic fibrosis (CF) is an autosomal recessive, life-limiting disease resulting from gene mutations that encode the cystic fib ...

Imagine a microscopic sniper, capable of delivering a lethal blow to a single cancer cell while leaving its healthy neighbors virtually untouched. This is the promise of targeted alpha therapy, a re ...

The CD28 molecule plays a crucial role in amplifying T cell activation, which is critical for mounting effective immune responses against tumors. By engaging with co-stimulatory molecule ...

By Ciara Coleman PhD General Introduction Coeliac Disease (CD) is defined as a common, chronic inflammatory di ...

Schwann cells are cells that play a vital role in nerve function. They are responsible for myelinating axons and helping to ensure the transmission of electrical signals between neurons. Schwann ...

Introduction T lymphocytes are type of white blood cell that plays a crucial role in the immune system. There are many different types of T cells, and it is important to be able to di ...

Agata Miezaniec PhD Candidate, University of Nottingham, UK Epigenetics and the link to DNA Methylation The term ‘Epigene ...

When PhDs and Post-Docs start in new lab they have the best intentions to keep their lab books up to date with notes, new research methods, data, and protocol information. These best efforts u ...

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Disease & Pathway ToolsEmpower you Biomedical ResearchDiscover high-quality tools for studying disease pathways, biomarker discovery, and therapeutic development. Ideal for immunolo ...

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TCA/Krebs Cycle Assays At Assay Genie we've developed a range of TCA assays for researchers to analyse key steps in the Krebs/TCA/Citric Acid cycle pathway. Different Products ...

PharmaGenie ELISA Validated According to ISO Quality Systems Highly validated ELISA designed to exceed the needs of biopharma R&D s ...

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