Blog
Androgenic steroid action in breast cancer
By Rachel Bleach, PhD Student, RCSI
By the age of 79 years, 1 in 14 women will develop breast cancer (Global Burden of Disease Cancer 2017). Beatson reported
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9th Mar 2021
AKT Signalling – Mini Review
Protein kinase B or AKT (PKB) is a serine/threonine kinase. In mammals it is comprised of 3 highly homologous isoforms PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) (Manning and Cantley 2007). A
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9th Mar 2021
Neutrophils - Cells of the Immune System
The immune system is the body’s main defence against infection. In order to function properly, the immune system must be able to detect and protect against infinite agents su
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8th Mar 2021
Carbon Dioxide sensing in Immune Cells
BRIEF HISTORY OF THE “GREEN” EVOLUTION OF OXYGEN AND CARBON DIOXIDE WITHIN OUR ATMOSPHERE
Million years ago carbon dioxide (CO2) levels used to be conside
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8th Mar 2021
How we can target the underlying immune processes in pathological inflammation in obesity, cancer and liver disease.
Dr. Melissa Conroy, TTMI
I am an immunologist and senior research fellow in the Cancer Immunology and Immunotherapy Group, Department of Surgery at Trinity
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8th Mar 2021
Sensing Danger: The Biology of TLR-Mediated Inflammation
By Eoin Mac Réamoinn
Toll-like receptors (TLRs) are renowned for their fundamental roles in innate sensing and initiating inflammatory responses. TLRs
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8th Mar 2021
SOCS proteins: Manipulating the immune response
Katherine Edwards, PhD Student, Queen’s University Belfast
Cytokines play a vital role in immune responses enabling cross-talk between different cell types a
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8th Mar 2021
Trauma Immunology
Traumatic injuries & death
When I ask people what the leading cause of death is in the United States in people age 44 and under, they generally reply saying
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8th Mar 2021
The Influence of dietary interventions upon platelet reactivity
Laura Menke PhD candidate, Queen Mary University of London
Inflammation vs. Resolution
Atherothrombosis is the leading cause of death worldwide
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8th Mar 2021
Multiple Sclerosis and Stem Cells
By Sonika Singh PhD candidate, University of Nottingham
A Devastating Disease
Multiple Sclerosis (MS) is a chronic and inflammatory disease bas
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8th Mar 2021
Interferons
Interferons (IFNs) are a group of signalling proteins that are produced and released from cells in response to viral infection and other stimuli such as normal and tumour cell surviv
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6th Mar 2021
LATS1/2 Kinases Review
LATS kinases belong to a family of proteins that, in mammals, are comprised of two isoforms, LATS1 and LATS2. Originally identified in Drosophila melanogaster as Warts kinase, LATS1 and LATS2
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11th Jan 2021
Phosphatases and PTP1B – Mini review
IntroductionThe human kinome is estimated to contain 518 genes, in comparison to the estimated 180 genes that comprise the phosphatome (Arena et al., 2005). These kinase genes represent a sign
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18th Dec 2020
Scientist in the spotlight
Delighted to be featured on Sophie Arthur’s blog, Soph Talks Science, where she interviews PhDs about their lives as researchers. Some great pieces on the site that are linkedin with the Insta
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18th Dec 2020
#LabChats with Laura Menke
At ELISA Genie we are hugely interested in the future of science and we feel that PhD students are at the heart of this. Our new series, #LabChats, will see us interview different scienti
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18th Dec 2020
Inhibiting cell division
Unregulated cell growthCancer, although heterogeneous by its very nature, can be broadly defined as a set of diseases characterised by unregulated cell growth leading to invasion of surround
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18th Dec 2020
Ras signaling pathway
A wide variety of cell surface receptors activate Ras GTPase, including the tyrosine receptor linked to the epidermal growth factor receptor (EGFR) (Wells 1999). Upon receptor stimulation, son
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18th Dec 2020
Spotlight on Mitochondria
Throughout my graduate and postgraduate studies I have been really intrigued and fascinated by the mitochondria, the organelle that keeps all of us running everyday! The more I learn about
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18th Dec 2020
IQGAP1 signaling review
IQGAP1: IQ-motif containing GTPase-activating-like protein-1 reviewIQ motif-containing GTPase-activating-like protein-1 (IQGAP1) is a 190 KDa protein that belongs to a conserved family of sc
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18th Dec 2020
Early Diagnosis is key: Pick the weed or allow it destroy the garden?
By Catríona Dowling, Post-Doc, RCSI
I want you to come on a journey with me where we are going to the botanic gardens. You will pick a section of the garden that is yours: yours to treasure
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18th Dec 2020
Cancer & Tumour Suppressors – Mini Review
Cancer DevelopmentCancer is a group of diseases that involves abnormal cell growth resulting in malignant tumours/ malignant neoplasms. Cancer is a leading cause of morbidity, with 14 million
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18th Dec 2020
Hippo Pathway Review
MST2/Hippo PathwayMammalian Sterile Twenty (MST) pathways have been identified as a homologue of the ste20 kinase from Saccharomyces cerevisiae (Creasy and Chernoff 1995). The MST2/Hippo pathw
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18th Dec 2020
10 Steps to increase lab productivity
How to increase lab productivityWhen you look back at some weeks in the lab it seems like you have achieved nothing and your lab productivity can be low. Your cloning hasn’t worked or your mic
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18th Dec 2020
Zebrafish against cretinism and hypotonia
By Natalia Siomava, PhD
Cretinism is a severe medical condition of intellectual disability caused by the deficiency of thyroid hormone (congenital hypothyroi
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18th Dec 2020