The TNFSF11 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0225) is a cutting-edge tool for researchers studying TNFSF11, a cytokine that plays a crucial role in bone metabolism, immune regulation, and the development of osteoclasts. This antibody, meticulously developed using advanced technology and raised in rabbits, exhibits high sensitivity and specificity for TNFSF11 in a variety of biological samples.TNFSF11, also known as RANKL, is a key mediator in bone remodeling and the regulation of immune responses. By targeting TNFSF11, researchers can investigate its involvement in diseases such as osteoporosis, rheumatoid arthritis, and cancer metastasis. The TNFSF11 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0225) is an essential tool for uncovering the molecular mechanisms behind these diseases and developing potential therapeutic interventions.
Validated for use in techniques such as Western blotting, immunohistochemistry, and flow cytometry, this antibody offers flexibility and reliability in experimental settings. Its high affinity for TNFSF11 ensures accurate and reproducible results, enabling researchers to gain valuable insights into the function and significance of TNFSF11 in various physiological and pathological conditions.Overall, the TNFSF11 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0225) is a powerful asset for researchers aiming to deepen their understanding of TNFS
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
