The Caspase-8 Polyclonal Antibody (CAB11324) is a valuable tool for researchers investigating the role of caspase-8 in apoptosis, inflammation, and immunity. Caspase-8 is a crucial enzyme involved in the initiation of cell death pathways and plays a key role in regulating immune responses. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.By binding to caspase-8 protein, this antibody enables researchers to detect and analyze caspase-8 levels in various cell types, making it an ideal choice for studies in immunology, oncology, and inflammatory diseases.
Understanding the function of caspase-8 is essential for developing targeted therapies for conditions such as cancer, autoimmune disorders, and infectious diseases.Overall, the Caspase-8 Polyclonal Antibody (CAB11324) is a reliable tool for researchers seeking to explore the mechanisms of cell death and immune regulation, with potential applications in drug discovery and personalized medicine.
Product Name:
Caspase-8 Rabbit Polyclonal Antibody
SKU:
CAB11324
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 4-480 of mouse Caspase 8 (NP_033942.1).
This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Purification Method:
Affinity purification
Gene ID:
12370
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using Caspase-8 Rabbit pAb (CAB11324) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
