ANP
ANP (natriuretic peptide A, encoded by the NPPA gene) is a member of the natriuretic peptide family implicated in extracellular fluid volume and electrolyte homeostasis. It is also known as PND and was previously called natriuretic peptide precursor A. Browse Assay Genie's current range of ANP research reagents below, or read on for the biology behind the target.
ANP may have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo, it promotes natriuresis. In vitro, it selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips. Natriuretic peptides as a group are implicated in the control of extracellular fluid volume and electrolyte homeostasis, which is why ANP is studied in cardiovascular and renal biology.
The NPPA gene encodes a large precursor that contains a signal peptide. Processing of this precursor releases two products: a peptide from the N-terminus with similarity to the vasoactive peptide cardiodilatin, and a peptide from the C-terminus with natriuretic-diuretic activity. UniProt records the mature protein as secreted, with additional annotation to the perikaryon and cell projections. The mouse and rat orthologues are both named Nppa.
HGNC places the gene in the natriuretic peptides group and lists the previous name natriuretic peptide precursor A. The ANP gene sits next to another member of the natriuretic peptide family on chromosome 1. Mutations in this gene have been associated with atrial fibrillation, familial type 6, which links ANP to inherited cardiac rhythm disorders as well as to fluid and electrolyte control.
ANP may contribute to cardio-renal homeostasis through regulation of natriuresis and vasodilation, making it a focus for studies of fluid balance.
Natriuretic peptides are implicated in control of extracellular fluid volume and electrolyte homeostasis, and ANP is a reference member of the family.
In vitro, ANP selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips, an unusual tissue selectivity to investigate.
Mutations in NPPA are associated with familial atrial fibrillation type 6, so the gene is relevant to inherited arrhythmia research.
ANP may have a role in cardio-renal homeostasis through regulation of natriuresis and vasodilation. In vivo it promotes natriuresis. In vitro it selectively vasodilates intestinal smooth muscle but not vascular smooth muscle strips. The wider natriuretic peptide family is implicated in extracellular fluid volume control.
The HGNC symbol is NPPA, and the approved name is natriuretic peptide A. Aliases include ANP and PND, and the previous name was natriuretic peptide precursor A. The gene encodes a precursor that is processed into an N-terminal peptide, related to cardiodilatin, and a C-terminal natriuretic-diuretic peptide.
Mutations in the NPPA gene have been associated with atrial fibrillation, familial type 6. Orthologues exist in both mouse and rat, where the gene is named Nppa. Check the datasheet of any product for its validated reactivity.
Other natriuretic peptides and cardiovascular markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P01160; product specifications from Assay Genie datasheets.