APOA2
APOA2 (apolipoprotein A2, also written apolipoprotein A-II or apo-A-II) is a secreted apolipoprotein and the second most abundant protein of high density lipoprotein (HDL) particles. It is thought to help stabilise HDL structure and to influence HDL metabolism. Browse Assay Genie's current range of APOA2 research reagents below, or read on for the biology behind the target.
APOA2 is a component of high density lipoprotein (HDL) particles, where it is the second most abundant protein. According to UniProt, it may stabilise HDL structure through its association with lipids, and it may also affect HDL metabolism. Because it is a lipid-associated structural protein, it is studied alongside other HDL apolipoproteins when researchers examine how lipoprotein particles are assembled and remodelled.
The APOA2 gene encodes apolipoprotein A-II, a secreted protein that belongs to the apolipoprotein A2 family. HGNC places it in the apolipoproteins gene group. In plasma the protein is found as a monomer, as a homodimer, or as a heterodimer with apolipoprotein D, so the form being measured can matter when designing an experiment. The mouse and rat orthologs are both named Apoa2, which allows work on the APOA2 gene and protein to be extended to rodent models.
Defects in the APOA2 gene may result in apolipoprotein A-II deficiency or hypercholesterolemia, which links the protein to lipid metabolism research. Related apolipoproteins that researchers often study in the same context include ApoA1, APOA4 and APOA5.
APOA2 is a major protein of HDL particles and may stabilise their structure, making it relevant to studies of HDL composition.
The protein may affect HDL metabolism, so it is examined when researchers investigate how lipoprotein particles are processed in plasma.
Defects in the APOA2 gene may result in hypercholesterolemia, connecting the protein to studies of disordered cholesterol handling.
Defects in the gene may cause apolipoprotein A-II deficiency, making APOA2 a focus for work on inherited apolipoprotein disorders.
APOA2 encodes apolipoprotein A-II, the second most abundant protein of HDL particles. UniProt annotates it as a protein that may stabilise HDL structure through its association with lipids and may affect HDL metabolism. It is secreted into plasma.
APOA2 is the HGNC symbol for apolipoprotein A2, previously named apolipoprotein A-II (apo-A-II). In plasma the protein is found as a monomer, a homodimer, or a heterodimer with apolipoprotein D. No other aliases are listed in the sources.
Mouse and rat both carry an ortholog named Apoa2. Defects in the human gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. Check the datasheet of any product for its validated reactivity before choosing a reagent for a given species.
Other apolipoproteins involved in HDL and lipid metabolism research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P02652; product specifications from Assay Genie datasheets.