B7-H3
B7-H3 (CD276) is a membrane protein of the immunoglobulin superfamily that is thought to take part in regulating T-cell-mediated immune responses. It is also known as B7H3 and B7RP-2, and its gene symbol is CD276. Browse Assay Genie's current range of B7-H3 research reagents below, or read on for the biology behind the target.
B7-H3 may participate in the regulation of T-cell-mediated immune responses. Reported roles include modulating CD4 T-cell responses, where isoform 1 and isoform 2 appear to be redundant. Isoform 2 has been shown to enhance the induction of cytotoxic T-cells and to selectively stimulate interferon gamma production in the presence of T-cell receptor signalling. The protein may also protect tumour cells by inhibiting natural-killer-mediated cell lysis, and it has been proposed as a marker for the detection of neuroblastoma cells.
Beyond tumour biology, B7-H3 may be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. It could also help provide the placenta and fetus with a suitable immunological environment throughout pregnancy. The CD276 gene encodes a membrane protein that belongs to the immunoglobulin superfamily and the BTN/MOG family, and HGNC classes it within the B7 family and the V-set and C2-set domain-containing groups. Mouse and rat both carry a Cd276 ortholog.
NCBI Gene notes an unusual pattern of expression: the transcript is ubiquitously expressed in normal tissues and solid tumours, but the protein is preferentially found only in tumour tissues. The 3' UTR of the transcript contains a target site for miR29 microRNA, and B7-H3 protein levels correlate inversely with miR29, which suggests regulation by this microRNA. Alternatively spliced transcript variants encode different isoforms. The protein is also listed under the name CD276 antigen.
B7-H3 protein is preferentially expressed in tumour tissue, and it may protect tumour cells by inhibiting natural-killer-mediated lysis.
B7-H3 is thought to regulate T-cell-mediated responses, including CD4 T-cell activity and interferon gamma production linked to T-cell receptor signalling.
B7-H3 may be involved in acute and chronic transplant rejection and in regulating lymphocytic activity at mucosal surfaces.
B7-H3 is proposed as a marker for neuroblastoma cells and may help create a suitable immunological environment for the placenta and fetus.
B7-H3 may participate in regulating T-cell-mediated immune responses. It may inhibit natural-killer-mediated lysis of tumour cells, influence CD4 and cytotoxic T-cell activity, and contribute to the immunological environment of the placenta and fetus. These roles are described in UniProt as possible rather than established.
B7-H3 is encoded by the CD276 gene and is also called B7H3, B7RP-2 and CD276 antigen. Alternatively spliced transcripts give different isoforms. Isoform 1 and isoform 2 both appear to modulate CD4 T-cell responses, while isoform 2 also enhances cytotoxic T-cell induction.
According to NCBI Gene, the CD276 transcript is ubiquitously expressed in normal tissues and solid tumours, yet the protein is preferentially expressed in tumour tissues. The transcript has a miR29 target site, and protein levels correlate inversely with miR29. Mouse and rat orthologs are both named Cd276.
Other CD molecules, immunoglobulin superfamily members and immune regulators with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q5ZPR3; product specifications from Assay Genie datasheets.