Chordin
Chordin, catalogued under the gene symbol VWC2 and named brorin in UniProt, is a secreted bone morphogenetic protein (BMP) antagonist. It is thought to contribute to neural development and has been reported to promote cell adhesion; PSST739 and UNQ739 are listed aliases. Browse Assay Genie's current range of Chordin research reagents below, or read on for the biology behind the target.
Chordin, as annotated under the HGNC symbol VWC2 (von Willebrand factor C domain containing 2), functions as an antagonist of bone morphogenetic proteins. BMPs are signalling molecules, and antagonists of this kind act in the extracellular space to modulate their activity. UniProt records that the protein may play a role in neural development and that it promotes cell adhesion. The NCBI Gene summary similarly describes the encoded protein as possibly involved in neural function and development, with a possible role in cell adhesion.
The VWC2 gene encodes a secreted protein. UniProt, where the entry is named brorin, places it in the extracellular space, within the extracellular matrix and basement membrane, and also at the synapse. This combination of matrix and synaptic localisation fits with the functions proposed in the literature for neural and adhesion-related biology, although the detailed mechanisms are not described in the source annotation. HGNC assigns the gene to the Chordin family, and the mouse ortholog is designated Vwc2, which makes the mouse a natural context for comparative work.
The same target appears in databases under several names. The HGNC name refers to the von Willebrand factor C domain, the UniProt recommended name is brorin, and PSST739 and UNQ739 are listed as aliases. Researchers searching for a Chordin antibody, Chordin ELISA kit or Chordin protein for this entry should therefore check that the gene symbol and UniProt accession match the intended target. Studies of this protein are relevant wherever BMP signalling, neural development and cell adhesion intersect.
As a secreted BMP antagonist, the protein is relevant to studies of how extracellular factors modulate bone morphogenetic protein signalling.
UniProt and NCBI Gene both indicate a possible role in neural function and development, making it a candidate for neurobiology research.
The protein is reported to promote cell adhesion, which supports its use in work on adhesion and the extracellular matrix.
Annotated locations in the basement membrane, extracellular matrix and synapse make it of interest for studying secreted proteins in these compartments.
UniProt describes it as a BMP antagonist that may play a role in neural development and promotes cell adhesion. NCBI Gene likewise calls the encoded protein a secreted bone morphogenetic protein antagonist, possibly involved in neural function and development, with a possible role in cell adhesion.
The HGNC gene symbol is VWC2, for von Willebrand factor C domain containing 2. UniProt names the protein brorin, and PSST739 and UNQ739 are listed aliases. No previous HGNC names are recorded. Check identifiers carefully when comparing records across databases.
A mouse ortholog, Vwc2, is recorded for this gene. No rat ortholog is given in the data supplied here, so check the datasheet of any product for its validated reactivity before planning cross-species experiments.
Other BMP ligands, BMP antagonists and Chordin family-related targets that may be of interest alongside this protein.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q2TAL6; product specifications from Assay Genie datasheets.