CXCL14
CXCL14 (C-X-C motif chemokine ligand 14) is a secreted chemokine of the intercrine alpha, or CXC, family. Also known as BRAK, bolekine, NJAC, Kec and MIP-2g, it is studied for its chemoattractant activity and its role in immune cell homeostasis. Browse Assay Genie's current range of CXCL14 research reagents below, or read on for the biology behind the target.
CXCL14 is a secreted chemokine that belongs to the intercrine alpha (chemokine CxC) family. UniProt annotates it as a potent chemoattractant for neutrophils and a weaker one for dendritic cells. The same annotation reports that it is not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes, and that it does not inhibit proliferation of myeloid progenitors in colony formation assays.
The NCBI Gene summary describes the activity differently. It states that this cytokine is chemotactic for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages, and suggests that it is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. Because the two sources disagree on which cell types respond, the target cell specificity of CXCL14 is best checked against the primary literature for the system you work in.
The CXCL14 gene is listed by HGNC in the chemokine ligands group, and its mouse ortholog is Cxcl14. NCBI classes it as an antimicrobial gene within the cytokine gene family, whose members encode secreted proteins involved in immunoregulatory and inflammatory processes. As a CXC subfamily member, the protein is characterised by two cysteines separated by a single amino acid. Earlier names include small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK), and the gene has also been recorded as SCYB14, NJAC, bolekine, Kec, MIP-2g, BMAC and KS1.
UniProt describes CXCL14 as a potent neutrophil chemoattractant, making it a candidate for studies of leukocyte recruitment and migration.
CXCL14 is annotated as a weaker chemoattractant for dendritic cells, relevant to work on how chemokines shape antigen-presenting cell movement.
NCBI links this cytokine to the homeostasis of monocyte-derived macrophages rather than to inflammation, framing studies of resident myeloid cell regulation.
As a CXC chemokine with distinct cell selectivity, CXCL14 is useful for comparing ligand specificity across the chemokine family.
CXCL14 is a secreted CXC chemokine. UniProt reports it as a potent chemoattractant for neutrophils and a weaker one for dendritic cells, with no chemotactic effect on T-cells, B-cells, monocytes or natural killer cells. NCBI instead describes monocyte chemotaxis and a role in macrophage homeostasis.
Aliases include BRAK, NJAC, bolekine, Kec, MIP-2g, BMAC, KS1 and SCYB14. Earlier HGNC names were small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK) and chemokine (C-X-C motif) ligand 14. These names all refer to the same gene.
A mouse ortholog, Cxcl14, is recorded for the human gene. A rat ortholog is not given in the data used here. Researchers working in other species should check the datasheet of any product for its validated reactivity.
Other CXC chemokine ligands involved in leukocyte migration and immunoregulatory signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O95715; product specifications from Assay Genie datasheets.