FcRn
FcRn (Fc gamma receptor and transporter, encoded by the FCGRT gene) is a receptor that binds the Fc region of monomeric immunoglobulin G. It transfers IgG across the placenta and protects the antibody from degradation; it is also known as FcgammaRn. Browse Assay Genie's current range of FcRn research reagents below, or read on for the biology behind the target.
FcRn is a receptor that binds the Fc region of monomeric immunoglobulin G. According to the NCBI Gene summary, it carries out two linked roles: it transfers IgG antibodies from mother to fetus across the placenta, and it binds IgG to protect the antibody from degradation. These functions make the FcRn protein a central subject in studies of IgG transport and IgG persistence.
The protein is annotated in UniProt as the IgG receptor FcRn large subunit p51 and is located at the cell membrane and the endosome membrane. It belongs to the immunoglobulin superfamily, and HGNC places the gene in the C1-set domain containing group. The FCGRT gene has mouse and rat orthologs, both named Fcgrt, and alternative splicing is reported to give multiple transcript variants.
Beyond its role with antibodies, UniProt records that FcRn acts as an uncoating receptor for a panel of echoviruses, including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29. This links the receptor to microbial infection as well as to immunoglobulin biology. Earlier HGNC names for the gene include Fc fragment of IgG, receptor, transporter, alpha, and Fc fragment of IgG receptor and transporter; the symbols FcgammaRn and FcRn remain in use as aliases.
FcRn moves IgG antibodies from mother to fetus across the placenta, making it a key target in studies of passive immunity.
By binding IgG and protecting it from degradation, FcRn is relevant to research on antibody handling and persistence.
As a receptor for the Fc region of monomeric IgG within the immunoglobulin superfamily, FcRn informs work on Fc-binding mechanisms.
FcRn acts as an uncoating receptor for several echoviruses, supporting research into viral entry and receptor usage.
FcRn binds the Fc region of monomeric immunoglobulin G. It transfers IgG antibodies from mother to fetus across the placenta and binds IgG to protect it from degradation. It also acts as an uncoating receptor for a panel of echoviruses.
The gene symbol is FCGRT, with the HGNC name Fc gamma receptor and transporter. Aliases include FcgammaRn and FcRn. UniProt names the protein IgG receptor FcRn large subunit p51. Earlier gene names referred to the Fc fragment of IgG receptor and transporter, alpha.
Yes. Mouse and rat each have an ortholog named Fcgrt. The human protein belongs to the immunoglobulin superfamily. Alternative splicing of the gene produces multiple transcript variants. Check the datasheet of any product for its validated reactivity.
Other Fc receptors, immunoglobulin-related proteins and antibody-handling targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P55899; product specifications from Assay Genie datasheets.