HB-EGF
HB-EGF (heparin binding EGF like growth factor, also known as HEGFL, DTS and DTR) is an EGF-family growth factor that signals through EGFR, ERBB2 and ERBB4. It is also the cellular receptor for diphtheria toxin. Browse Assay Genie's current range of HB-EGF research reagents below, or read on for the biology behind the target.
HB-EGF is a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. It binds the EGF receptor with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. It is mitogenic for fibroblasts but not for endothelial cells, and it may be involved in macrophage-mediated cellular proliferation. Gene annotation also records heparin binding activity and transmembrane receptor protein tyrosine kinase activator activity, and places HB-EGF in cell chemotaxis, positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of wound healing.
The HBEGF gene encodes a precursor, proheparin-binding EGF-like growth factor. The protein is found both in the extracellular space and at the cell membrane, and it is located at the cell surface. HB-EGF is required for normal cardiac valve formation and normal heart function, and it promotes smooth muscle cell proliferation. Researchers working with the HB-EGF protein often study it within the epidermal growth factor receptor signalling pathway.
HB-EGF belongs to the EGF ligand family. Its earlier names, diphtheria toxin receptor and heparin-binding epidermal growth factor-like growth factor, reflect two features: it acts as the receptor for diphtheria toxin, and it binds heparin. NCBI Gene summarises disease associations for HBEGF that include congestive heart failure, dilated cardiomyopathy, glomerulosclerosis, perinatal necrotizing enterocolitis and type 1 diabetes mellitus. The mouse and rat orthologues are both named Hbegf, which supports comparative work in rodent models.
HB-EGF acts through EGFR, ERBB2 and ERBB4 and binds EGFR with higher affinity than EGF, making it a useful ligand for receptor studies.
HB-EGF is required for normal cardiac valve formation and heart function, and is implicated in congestive heart failure and dilated cardiomyopathy.
HB-EGF is mitogenic for fibroblasts and smooth muscle cells and is involved in positive regulation of wound healing and cell chemotaxis.
HB-EGF also acts as the diphtheria toxin receptor, which is the basis of its alternative names DTR and DTS.
HB-EGF is a growth factor that signals via EGFR, ERBB2 and ERBB4. It promotes smooth muscle cell proliferation, is mitogenic for fibroblasts but not endothelial cells, and is required for normal cardiac valve formation and heart function.
The HGNC symbol is HBEGF, and aliases include HEGFL, DTS and DTR. Earlier names are diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) and heparin-binding EGF-like growth factor. UniProt lists the precursor as proheparin-binding EGF-like growth factor.
NCBI Gene reports that HBEGF is implicated in congestive heart failure, dilated cardiomyopathy, glomerulosclerosis, perinatal necrotizing enterocolitis and type 1 diabetes mellitus. Mouse and rat both have an orthologue named Hbegf; check the datasheet of any product for its validated reactivity.
Other EGF-family ligands and their ErbB receptors, which act in the same signalling pathway as HB-EGF.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q99075; product specifications from Assay Genie datasheets.