IL-17F
IL-17F (interleukin 17F, also known as ML-1 or ML1) is a secreted effector cytokine of the innate and adaptive immune system, and a member of the IL-17 family. It contributes to antimicrobial host defence and the maintenance of tissue integrity. Browse Assay Genie's current range of IL-17F research reagents below, or read on for the biology behind the target.
IL-17F is a signature effector cytokine of T-helper 17 (Th17) cells. It acts mainly on neutrophils, driving their activation and recruitment to sites of infection and inflammation, and so supports defence against extracellular bacteria and fungi. IL-17F can signal as a homodimer through an IL-17RC homodimeric receptor complex, which triggers TRAF6 and NF-kappa-B signalling. It also forms an IL-17A-IL-17F heterodimer that signals via the IL-17RA-IL-17RC receptor complex. In that case, IL-17RA and IL-17RC engage the TRAF3IP2 adapter through their SEFIR domains, leading to TRAF6-mediated activation of NF-kappa-B and MAP kinase pathways. The result is transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases.
Beyond neutrophil responses, IL-17F stimulates mucosal epithelial cells to produce the beta-defensins DEFB1, DEFB103A and DEFB104A, which limit microbial entry across epithelial barriers. Via IL-17RC it induces IL-33, a cytokine that stimulates group 2 innate lymphoid cells and T-helper 2 cells in the pulmonary allergic response to fungi. It also regulates intestinal microbiota and immune tolerance by inducing antimicrobial proteins that control commensal Firmicutes and Bacteroidetes, and it promotes sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression.
The IL-17F gene encodes a protein with sequence similarity to IL-17A and is expressed by activated T cells. NCBI Gene notes that it stimulates production of IL-6, IL-8 and GM-CSF, inhibits angiogenesis of endothelial cells, and induces endothelial cells to produce IL-2, TGF-beta and monocyte chemoattractant protein-1. Orthologous genes are annotated in mouse and rat as Il17f.
IL-17F is a signature Th17 effector that activates and recruits neutrophils to infection and inflammatory sites.
It induces beta-defensins in mucosal epithelial cells, limiting microbial entry across epithelial barriers.
IL-17F induces antimicrobial proteins that control commensal Firmicutes and Bacteroidetes, shaping intestinal microbiota and immune tolerance.
Via IL-17RC it induces IL-33 in pulmonary allergic responses and promotes sympathetic innervation of thermogenic adipose tissue.
IL-17F is an effector cytokine of Th17 cells that activates and recruits neutrophils, supporting defence against extracellular bacteria and fungi. It signals through IL-17RC, with TRAF6, NF-kappa-B and MAP kinase pathways, to induce cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases.
The HGNC gene name is interleukin 17F, symbol IL17F, with aliases ML-1 and ML1. UniProt lists the protein as Interleukin-17F. It belongs to the IL-17 family and can also form a heterodimer with IL-17A (IL17A-IL17F).
Yes. Orthologous genes named Il17f are annotated in both mouse and rat. Researchers working across species should check the datasheet of any product for its validated reactivity before use.
Other IL-17 family cytokines and Th17-associated interleukins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q96PD4; product specifications from Assay Genie datasheets.