IL-19
IL-19 (interleukin 19) is a secreted cytokine of the IL-10 family that acts as an anti-inflammatory and proangiogenic factor. It is also known as MDA1, ZMDA1, IL-10C and NG.1, and signals through the IL-20 receptor complex. Browse Assay Genie's current range of IL-19 research reagents below, or read on for the biology behind the target.
IL-19 is a cytokine that functions as an anti-inflammatory and proangiogenic factor. It polarises adaptive immunity towards an anti-inflammatory phenotype by promoting T-helper 2 responses, both by down-regulating IFN-gamma and by up-regulating IL-4 and IL-13. IL-19 produced by osteocytes stimulates granulopoiesis and neutrophil formation. It exerts its effects through a receptor complex that is a heterodimer of IL20RA and IL20RB. Receptor engagement activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and in particular STAT3.
The IL19 gene encodes a secreted protein that belongs to the IL-10 family and to the IL-10 cytokine subfamily. According to the NCBI Gene summary, IL-19 is preferentially expressed in monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described. The gene sits within the HGNC group of interleukins and the interleukin 10 family, alongside related cytokines such as IL-10, IL-20 and IL-24.
IL-19 is also listed under the names MDA1, ZMDA1, IL-10C and NG.1. A similar cytokine in mouse (Il19) is reported to up-regulate IL-6 and TNF-alpha and to induce apoptosis, which suggests a role for this cytokine in inflammatory responses. Researchers studying IL-19 biology, whether with an IL-19 antibody, an IL-19 ELISA kit or recombinant IL-19 protein, often examine it together with other IL-10 family members that share the IL-20 receptor complex.
IL-19 is an anti-inflammatory cytokine that is reported to up-regulate IL-6 and TNF-alpha in mouse, making it relevant to inflammatory response research.
IL-19 drives T-helper 2 responses by down-regulating IFN-gamma and up-regulating IL-4 and IL-13, which makes it useful for studying adaptive immune skewing.
IL-19 signals through the IL20RA and IL20RB heterodimer to activate the JAK/STAT pathway, with STAT3 as a key mediator.
IL-19 is described as proangiogenic, and osteocyte-derived IL-19 stimulates granulopoiesis and neutrophil formation.
IL-19 is a secreted cytokine with anti-inflammatory and proangiogenic activity. It promotes T-helper 2 responses by lowering IFN-gamma and raising IL-4 and IL-13. It signals through an IL20RA and IL20RB receptor heterodimer, activating the JAK/STAT pathway, especially STAT3. Check the datasheet of any product for its validated reactivity.
IL-19 is also known as MDA1, ZMDA1, IL-10C and NG.1, and the official gene symbol is IL19. NCBI Gene reports that alternatively spliced transcript variants encode distinct isoforms. UniProt lists the protein as interleukin-19, a member of the IL-10 family.
A mouse ortholog, Il19, exists. NCBI Gene reports that a similar mouse cytokine up-regulates IL-6 and TNF-alpha and induces apoptosis, suggesting a role in inflammatory responses. In humans, IL-19 is preferentially expressed in monocytes. Check the datasheet of any product for its validated reactivity.
Other IL-10 family cytokines, Th2-associated interleukins and inflammatory mediators connected to IL-19 signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9UHD0; product specifications from Assay Genie datasheets.