IL-20
IL-20 (interleukin 20, also known as ZCYTO10 or IL10D) is a secreted pro-inflammatory and angiogenic cytokine of the IL-10 family. It is mainly produced by monocytes and skin keratinocytes and contributes to immune responses and epidermal function. Browse Assay Genie's current range of IL-20 research reagents below, or read on for the biology behind the target.
IL-20 is a pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes. It plays roles in immune responses, regulation of inflammatory responses, haemopoiesis, and epidermal cell and keratinocyte differentiation. It enhances tissue remodelling and wound-healing activities and helps restore the homeostasis of epithelial layers during infection and inflammation, maintaining tissue integrity. In activated neutrophils it affects several actin-mediated functions, leading to inhibition of phagocytosis, granule exocytosis and migration.
IL-20 signals through the type I IL-20 receptor complex, made up of IL20RA and IL20RB. It can alternatively act through a type II receptor complex composed of IL22RA1 and IL20RB. Downstream, it acts as an arteriogenic and vascular remodelling factor by driving phosphorylation of JAK2 and STAT5 and activating the serine/threonine kinases AKT and ERK1/2. In keratinocytes it can activate STAT3 phosphorylation and transcriptional activity in a manner dependent on JAK2, ERK1/2 and p38 MAPK.
The IL20 gene encodes a secreted protein that belongs to the IL-10 family and is structurally related to IL-10. Other names include ZCYTO10 and IL10D. A specific receptor for IL-20 is expressed in skin and is upregulated dramatically in psoriatic skin, which suggests a role for this cytokine in epidermal function and psoriasis. The mouse ortholog is designated Il20.
A receptor for IL-20 is upregulated dramatically in psoriatic skin, pointing to a role in epidermal function and psoriatic disease.
IL-20 activates STAT3 in keratinocytes through JAK2, ERK1/2 and p38 MAPK, and influences keratinocyte differentiation.
This pro-inflammatory cytokine regulates inflammatory responses and modulates neutrophil phagocytosis, granule exocytosis and migration.
IL-20 acts as an arteriogenic and vascular remodelling factor and enhances wound-healing and tissue remodelling activities.
IL-20 is a secreted cytokine made mainly by monocytes and skin keratinocytes. It regulates immune and inflammatory responses, keratinocyte differentiation and haemopoiesis, and promotes wound healing and vascular remodelling. In activated neutrophils it inhibits phagocytosis, granule exocytosis and migration.
IL-20 signals through the type I receptor complex of IL20RA and IL20RB, or the type II complex of IL22RA1 and IL20RB. Downstream effects include JAK2, STAT5, AKT and ERK1/2 activation, and STAT3 phosphorylation in keratinocytes.
IL-20 belongs to the IL-10 family and is structurally related to IL-10. Its receptor is strongly upregulated in psoriatic skin, suggesting a role in psoriasis. A mouse ortholog, Il20, exists; check the datasheet of any product for its validated reactivity.
Other IL-10 family cytokines and interleukins involved in skin inflammation and epithelial immunity.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NYY1; product specifications from Assay Genie datasheets.