IL-23
IL-23 is a pro-inflammatory heterodimeric cytokine formed when the interleukin 23 subunit alpha (IL23A, also known as p19, IL-23A, SGRF or IL23P19) associates with the p40 subunit IL12B. It acts in both innate and adaptive immunity. Browse Assay Genie's current range of IL-23 research reagents below, or read on for the biology behind the target.
IL-23 is a secreted, pro-inflammatory cytokine that plays different roles in innate and adaptive immunity. The IL23A gene encodes the alpha subunit (p19), which associates with the p40 subunit of interleukin-12 (IL12B) to form the active heterodimer. It is released by antigen-presenting cells such as dendritic cells and macrophages.
IL-23 signals through a heterodimeric receptor complex made up of IL12RB1 and an IL-23-specific subunit, IL23R. Receptor engagement activates JAK2 and TYK2, which phosphorylate the receptor to create a docking site that leads to phosphorylation of STAT3 and STAT4. This drives several downstream pathways, including p38 MAPK and NF-kappa-B, and promotes production of pro-inflammatory cytokines such as IL-17A. In turn, IL-23 participates in early and effective intracellular bacterial clearance.
IL-23 promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells. Like IL-12, it can activate STAT4 and stimulate interferon-gamma production, but whereas IL-12 acts mainly on naive CD4-positive T cells, IL-23 preferentially acts on memory CD4-positive T cells. The p19 subunit belongs to the IL-6 superfamily and is classed by HGNC among the interleukin 12 type subunits; its previous name was interleukin 23, alpha subunit p19. Researchers study the IL-23 protein and the IL23A gene in the context of these immune pathways.
IL-23 promotes the expansion and survival of T-helper 17 cells and other IL-17-producing cells, making it central to studies of this lineage.
IL-23 from dendritic cells and macrophages participates in early and effective intracellular bacterial clearance.
IL-23 engages IL12RB1 and IL23R to activate JAK2, TYK2, STAT3 and STAT4, offering a model for JAK-STAT pathway analysis.
Unlike IL-12, IL-23 preferentially acts on memory CD4-positive T cells, which makes it useful for comparing T-cell subset regulation.
IL-23 is a pro-inflammatory cytokine released by dendritic cells and macrophages. It signals through IL12RB1 and IL23R, activating JAK2, TYK2, STAT3 and STAT4, and promotes IL-17A production and the expansion and survival of T-helper 17 cells.
IL23A encodes the alpha subunit, also called p19. This subunit pairs with the p40 subunit IL12B to form the heterodimeric cytokine IL-23. Other aliases include SGRF, IL23P19 and IL-23A. The earlier name was interleukin 23, alpha subunit p19.
Mouse and rat both have an ortholog, named Il23a. The human protein belongs to the IL-6 superfamily and is grouped by HGNC with the interleukin 12 type subunits. Check the datasheet of any product for its validated reactivity.
Other interleukins, IL-12 family cytokines and IL-17 pathway targets that are closely linked to IL-23 biology.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9NPF7; product specifications from Assay Genie datasheets.