MMP-1
MMP-1 (matrix metallopeptidase 1, also known as interstitial collagenase or CLG) is a secreted member of the M10 family of matrix metalloproteinases. It cleaves interstitial collagens and contributes to extracellular matrix breakdown in tissue remodelling and disease. Browse Assay Genie's current range of MMP-1 research reagents below, or read on for the biology behind the target.
MMP-1 is a collagenase that cleaves collagens of types I, II and III at a single site in the helical domain. It also cleaves collagens of types VII and X. As a secreted protease of the extracellular space and extracellular matrix, it belongs to the peptidase M10A family and is classed by HGNC among the M10 matrix metallopeptidases and receptor ligands.
The MMP1 gene encodes a preproprotein that is proteolytically processed to generate the mature protease. Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodelling, as well as in disease processes, such as arthritis and metastasis. The gene lies within a cluster of MMP genes on chromosome 11, and alternative splicing produces multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
In HIV infection, MMP-1 interacts with and cleaves the secreted viral Tat protein, which decreases the neurotoxicity mediated by neuronal Tat. Mutations in the gene are associated with chronic obstructive pulmonary disease (COPD). The protein was previously named matrix metalloproteinase 1 (interstitial collagenase), and the rat ortholog is Mmp1. Researchers studying MMP-1 often use it alongside other MMPs to examine collagen turnover and matrix remodelling.
MMP-1 breaks down interstitial collagens, making it a central enzyme for studying matrix turnover in development, reproduction and tissue remodelling.
Matrix metalloproteinases such as MMP-1 are implicated in disease processes including arthritis and metastasis, where extracellular matrix degradation is a key feature.
Mutations in the MMP1 gene are associated with chronic obstructive pulmonary disease, linking collagenase biology to lung disease research.
MMP-1 cleaves the secreted HIV Tat protein, reducing Tat-mediated neuronal toxicity, which makes it relevant to neuro-infection studies.
MMP-1 is a secreted collagenase that cleaves collagens of types I, II and III at one site in the helical domain, and also types VII and X. This breaks down the extracellular matrix during normal tissue remodelling and in disease.
MMP-1 is also called interstitial collagenase and CLG. The HGNC name is matrix metallopeptidase 1, and an earlier name was matrix metalloproteinase 1 (interstitial collagenase). The enzyme is classified as EC 3.4.24.7 in the peptidase M10A family.
The NCBI Gene summary links mutations in MMP1 to chronic obstructive pulmonary disease. MMP family proteins are also involved in arthritis and metastasis. In HIV infection, MMP-1 cleaves viral Tat protein. Check the datasheet of any product for its validated reactivity.
Other matrix metalloproteinases, including collagenases, gelatinases and stromelysins, that are studied alongside MMP-1.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P03956; product specifications from Assay Genie datasheets.