MOG
MOG (myelin oligodendrocyte glycoprotein, also known as BTN6 or BTNL11) is a cell-surface membrane protein found on oligodendrocytes and on the outermost surface of myelin sheaths. It is a primary target antigen in immune-mediated demyelination. Browse Assay Genie's current range of MOG research reagents below, or read on for the biology behind the target.
MOG is a membrane protein expressed on the oligodendrocyte cell surface and on the outermost surface of myelin sheaths. This position leaves it exposed to the immune system, and it is described as a primary target antigen in immune-mediated demyelination. The protein may also contribute to the completion and maintenance of the myelin sheath and to cell-cell communication. In the context of microbial infection, UniProt annotates MOG as a receptor for rubella virus.
The MOG protein belongs to the immunoglobulin superfamily and the BTN/MOG family. HGNC places the MOG gene in the butyrophilin and V-set domain containing gene groups, which is reflected in the earlier symbols BTN6 and BTNL11. The protein is localised to the cell membrane. Alternatively spliced transcript variants of the MOG gene encode different isoforms, so researchers working with a particular MOG antibody or MOG ELISA kit should consider which forms are relevant to their question.
Because MOG sits at the myelin surface and is a recognised autoimmune target, it is widely studied in demyelination, myelin biology and neuroimmunology. Mouse and rat both carry a Mog ortholog, which allows the protein to be examined across common experimental models of myelin and immune-mediated disease.
MOG is a primary target antigen in immune-mediated demyelination, making it central to studies of how myelin is attacked.
The protein may help complete and maintain the myelin sheath, so it is relevant to myelin structure and upkeep.
MOG is expressed on the oligodendrocyte surface and outer myelin, offering a marker for oligodendrocyte and myelin membranes.
UniProt annotates MOG as a receptor for rubella virus, linking it to studies of viral entry.
MOG is a membrane protein on oligodendrocytes and the outer surface of myelin sheaths. It may be involved in completing and maintaining the myelin sheath and in cell-cell communication. It is also a primary target antigen in immune-mediated demyelination.
MOG stands for myelin oligodendrocyte glycoprotein. Earlier or alternative symbols are BTN6 and BTNL11. NCBI Gene reports that alternatively spliced transcript variants of the MOG gene encode different isoforms.
Mouse and rat both have a Mog ortholog. The protein belongs to the immunoglobulin superfamily and the BTN/MOG family. Check the datasheet of any product for its validated reactivity.
Other targets with products at Assay Genie that share a similar gene symbol.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q16653; product specifications from Assay Genie datasheets.