Neuropilin-1
Neuropilin-1 (NRP1, also known as NRP, VEGF165R and CD304) is a member of the neuropilin family that binds VEGF-165 and semaphorin family members. It acts in signalling pathways controlling cell survival, migration and attraction. Browse Assay Genie's current range of Neuropilin-1 research reagents below, or read on for the biology behind the target.
Neuropilin-1 binds VEGF-165 and may inhibit its binding to cells. By sequestering VEGF-165 it may induce apoptosis, and it may also bind various members of the semaphorin family. According to the UniProt annotation, its expression has an adverse effect on blood vessel number and integrity. Neuropilins bind many ligands and several types of co-receptor, and through these interactions they affect cell survival, migration and attraction.
The NRP1 gene encodes one of two neuropilins, the other being NRP2. The protein has a large N-terminal extracellular domain made up of complement-binding, coagulation factor V/VIII and meprin domains, followed by a short membrane-spanning domain and a small cytoplasmic domain. This architecture lets neuropilins take part in several different signalling pathways that control cell migration. UniProt lists multiple subcellular locations for Neuropilin-1: the cell membrane, mitochondrion membrane, cytoplasm, and a secreted form.
Neuropilin-1 is classified in the HGNC gene groups for CD molecules and the neuropilin family, and is also referred to as CD304. The alias VEGF165R reflects its role as a receptor for VEGF-165. Neuropilin-1 has also been shown to act as a co-receptor for SARS-CoV-2, the virus that causes COVID-19, helping it infect host cells. This has made the protein relevant to virology as well as to vascular and neuronal biology. Mouse and rat orthologs are both named Nrp1.
Neuropilin-1 binds VEGF-165 and can sequester it, making it a point of study for VEGF-dependent signalling and blood vessel integrity.
Neuropilin-1 binds semaphorin family members, so it is studied in signalling that controls cell migration and attraction.
Neuropilins bind many ligands and co-receptors that affect cell survival, migration and attraction, and Neuropilin-1 is used to dissect these pathways.
Neuropilin-1 acts as a co-receptor for SARS-CoV-2, which makes it relevant to research on viral infection of host cells.
Neuropilin-1 binds VEGF-165 and may inhibit its binding to cells, and it may bind semaphorin family members. Together with various co-receptors it contributes to signalling that affects cell survival, migration and attraction. It also acts as a co-receptor for SARS-CoV-2.
The gene symbol is NRP1, and the protein is also called NRP, VEGF165R and CD304. HGNC names the gene neuropilin 1. The alias VEGF165R refers to its binding of VEGF-165, while CD304 reflects its place among CD molecules.
Yes. Both mouse and rat have an ortholog named Nrp1, which allows rodent models to be used in Neuropilin-1 research. Humans also have a second neuropilin, NRP2. Check the datasheet of any product for its validated reactivity.
The second neuropilin family member, NRP2, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O14786; product specifications from Assay Genie datasheets.