Oncostatin M
Oncostatin M is a cytokine of the IL-6 family that signals through the shared receptor subunit encoded by IL6ST, also known as GP130, CD130 or IL-6RB. This page covers Oncostatin M and its signal transducer, a type I cytokine receptor subunit used by several cytokines. Browse Assay Genie's current range of Oncostatin M research reagents below, or read on for the biology behind the target.
Oncostatin M is one of several cytokines that rely on a common signal transducer, the interleukin 6 cytokine family signal transducer encoded by IL6ST. The same subunit is shared by interleukin 6 (IL-6), ciliary neurotrophic factor (CNTF) and leukaemia inhibitory factor (LIF). It functions as part of a cytokine receptor complex, and its activation depends on cytokines first binding their respective receptors. A viral IL-6 relative, vIL6, encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the IL-6 receptor and activate this protein directly.
The IL6ST gene encodes a protein of the type I cytokine receptor family, type 2 subfamily. It is found at the cell membrane and also as a secreted form. The soluble form, sGP130, binds the IL-6:sIL-6R complex (hyper-IL-6) and so blocks IL-6 trans-signalling, inhibiting the sIL-6R-dependent acute phase response. It also blocks IL-11 cluster signalling through IL-11R. This makes the membrane and soluble forms useful reference points when studying how Oncostatin M and related cytokines are controlled.
The protein is also known as GP130, CD130 and IL-6RB, and earlier HGNC names described it as the interleukin 6 signal transducer (gp130, oncostatin M receptor). HGNC places it among the CD molecules, fibronectin type III domain containing proteins and interleukin receptors. Knockout studies in mice suggest the gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described, and a related pseudogene lies on chromosome 17. Mouse and rat both carry an Il6st ortholog.
IL6ST is the signal transducer shared by IL-6, CNTF, LIF and Oncostatin M, making it central to studies of this receptor complex.
The soluble form binds the IL-6:sIL-6R complex and blocks trans-signalling, which makes it relevant to work on the sIL-6R-dependent acute phase response.
Soluble GP130 is annotated as blocking IL-11 cluster signalling through IL-11R, linking this target to IL-11 biology.
Kaposi sarcoma-associated herpesvirus vIL6 can bypass IL-6R and activate this protein directly, a route studied in viral signalling.
Oncostatin M is among the cytokines that use the shared signal transducer encoded by IL6ST (GP130). This protein acts as part of a cytokine receptor complex, and its activation depends on cytokines binding their receptors. IL-6, CNTF and LIF use the same subunit.
IL6ST is also written GP130, CD130, sGP130 and IL-6RB. Earlier HGNC names were interleukin 6 signal transducer (gp130, oncostatin M receptor). UniProt lists it as interleukin-6 receptor subunit beta. Alternatively spliced transcript variants have been described, and a membrane and a secreted form are annotated.
Mouse and rat both have an Il6st ortholog. Knockout studies in mice suggest the gene plays a critical role in regulating myocyte apoptosis. Check the datasheet of any product for its validated reactivity.
Other IL-6 family cytokines, receptor partners and interleukins that share or modulate GP130 signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P40189; product specifications from Assay Genie datasheets.