SERPINA6
SERPINA6, also known as corticosteroid-binding globulin (CBG), is a secreted alpha-globulin and a member of the serpin family. It is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. Browse Assay Genie's current range of SERPINA6 research reagents below, or read on for the biology behind the target.
SERPINA6 is the major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. The protein is an alpha-globulin with corticosteroid-binding properties, and it is released into the circulation, consistent with its annotation as a secreted protein. Its role as a carrier makes it central to how steroid hormones are held and moved in blood, which is why the SERPINA6 protein is studied in endocrinology and steroid biology.
The SERPINA6 gene encodes corticosteroid-binding globulin, abbreviated CBG, and the protein belongs to the serpin family. HGNC places it in the group of serpin peptidase inhibitors. Mouse and rat each have an orthologous gene, also named Serpina6, so the target can be considered across common model species. The gene sits in a chromosomal region that contains several closely related serine protease inhibitor genes, which may have evolved by duplication events.
The official name, serpin family A member 6, replaced earlier names that placed the protein in clade A of the alpha-1 antiproteinase, antitrypsin serpins, as serine (or cysteine) proteinase inhibitor, clade A, member 6. Neighbouring family members such as SERPINA1, SERPINA3 and SERPINA7 share this nomenclature, which reflects the shared evolutionary origin of the cluster. Researchers looking at SERPINA6 often work alongside these related serpins when comparing transport and inhibitor functions within the family.
SERPINA6 is the major blood transport protein for glucocorticoids and progestins, making it a key subject for studying how these hormones circulate.
As a corticosteroid-binding alpha-globulin, CBG is relevant to work on glucocorticoid and progestin biology in vertebrate blood.
The gene lies in a cluster of related serine protease inhibitors that may have arisen by duplication, supporting comparative studies.
Orthologous Serpina6 genes in mouse and rat, and a transport role across most vertebrates, support comparative physiology studies.
SERPINA6, or corticosteroid-binding globulin, is the major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. It is an alpha-globulin with corticosteroid-binding properties and is secreted into the circulation.
SERPINA6 is also called CBG, and UniProt names the protein corticosteroid-binding globulin. Earlier HGNC names described it as serine (or cysteine) proteinase inhibitor, clade A, member 6, or serpin peptidase inhibitor, clade A, member 6.
Mouse and rat both carry a Serpina6 ortholog, and the protein transports steroids in most vertebrates. It belongs to the serpin family, and its gene lies near related serine protease inhibitor genes that may have arisen by duplication. Check the datasheet of any product for its validated reactivity.
Other serpin family A members from the same gene cluster, studied alongside this steroid transport protein.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08185; product specifications from Assay Genie datasheets.