VEGF-B
VEGF-B (vascular endothelial growth factor B, also known as VEGFL or VRF) is a secreted growth factor for endothelial cells and a member of the PDGF/VEGF family. It acts as a ligand for VEGFR-1 and neuropilin-1. Browse Assay Genie's current range of VEGF-B research reagents below, or read on for the biology behind the target.
VEGF-B is a growth factor for endothelial cells. Like other members of the VEGF family, it contributes to the regulation of blood vessel formation and to endothelial cell physiology. It is a secreted protein and acts as a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and for NRP-1 (neuropilin-1).
The VEGFB gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF family, and it is assigned to the VEGF family gene group by HGNC. Alternatively spliced transcript variants encode distinct isoforms. Two are described in the UniProt annotation: VEGF-B167 binds heparin and neuropilin-1, whereas the binding of VEGF-B186 to neuropilin-1 is regulated by proteolysis. Orthologues of the human gene are named Vegfb in both mouse and rat, so the protein can be studied in common rodent models.
Studies in mice showed that the VEGFB gene was co-expressed with nuclear-encoded mitochondrial genes, and that the encoded protein specifically controlled endothelial uptake of fatty acids. This sets VEGF-B apart from other VEGF family members, which are mainly discussed in terms of vessel formation, and links it to endothelial metabolism. Researchers working on the VEGF-B protein, whether in expression studies or in assays of receptor and co-receptor binding, will find its isoform-specific behaviour an important point to consider in experimental design.
VEGF-B is a growth factor for endothelial cells and is involved in endothelial cell physiology, making it relevant to studies of the vascular endothelium.
As a VEGF family member, VEGF-B contributes to the regulation of blood vessel formation, alongside related PDGF/VEGF growth factors.
In mice, VEGF-B specifically controlled endothelial uptake of fatty acids and was co-expressed with nuclear-encoded mitochondrial genes.
VEGF-B is a ligand for VEGFR-1 and neuropilin-1, and isoform binding to neuropilin-1 differs, notably through proteolytic regulation of VEGF-B186.
VEGF-B is a secreted growth factor for endothelial cells. It belongs to the VEGF family, whose members regulate blood vessel formation and endothelial physiology. It is a ligand for VEGFR-1 and neuropilin-1, and in mice it specifically controlled endothelial uptake of fatty acids.
VEGF-B is also known as VEGFL and VRF, and its full name is vascular endothelial growth factor B. Alternative splicing gives distinct isoforms, including VEGF-B167, which binds heparin and neuropilin-1, and VEGF-B186, whose neuropilin-1 binding is regulated by proteolysis.
Yes. The mouse and rat orthologues are both named Vegfb, and mouse studies provided evidence that the protein controls endothelial fatty acid uptake and is co-expressed with nuclear-encoded mitochondrial genes. Check the datasheet of any product for its validated reactivity.
Other VEGF family growth factors, their receptors and co-receptors, and related endothelial biology targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P49765; product specifications from Assay Genie datasheets.