VEGF-D
VEGF-D (vascular endothelial growth factor D, also known as FIGF) is a secreted growth factor of the PDGF/VEGF family. It acts in angiogenesis, lymphangiogenesis and endothelial cell growth, signalling through VEGFR-2 and VEGFR-3. Browse Assay Genie's current range of VEGF-D research reagents below, or read on for the biology behind the target.
VEGF-D is a growth factor that stimulates the proliferation and migration of endothelial cells. It is active in angiogenesis, the growth of new blood vessels, and in lymphangiogenesis, the growth of lymphatic vessels, and it also affects the permeability of blood vessels. It binds and activates two receptor tyrosine kinases, VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4).
Functionally, VEGF-D may contribute to the formation of the venous and lymphatic vascular systems during embryogenesis, and to the maintenance of differentiated lymphatic endothelium in adults. The secreted protein undergoes a complex proteolytic maturation, which generates multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. Researchers working with the VEGF-D protein therefore need to consider which processed form they are measuring or targeting.
The VEGF-D gene (VEGFD, previously FIGF) encodes a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, and the HGNC lists it in the VEGF family gene group. Its earlier name was c-fos induced growth factor. The protein is structurally and functionally similar to vascular endothelial growth factor C. Mouse and rat orthologs, both named Vegfd, are recognised. Read-through transcription has been observed between this locus and the upstream PIR locus, which is worth remembering when interpreting transcript-level data.
VEGF-D stimulates endothelial cell proliferation and migration and affects blood vessel permeability, making it a relevant factor in studies of vessel growth.
VEGF-D is active in lymphangiogenesis and may maintain differentiated lymphatic endothelium in adults, supporting work on lymphatic biology.
VEGF-D binds and activates VEGFR-2 and VEGFR-3, so it is used to examine signalling through these two receptors.
VEGF-D may function in forming the venous and lymphatic vascular systems during embryogenesis, informing developmental vascular biology.
VEGF-D is a secreted growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth. It stimulates endothelial proliferation and migration, influences blood vessel permeability, and binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4). It may also maintain differentiated lymphatic endothelium in adults.
The gene symbol is VEGFD, with FIGF as a previous symbol and c-fos induced growth factor as the previous name. The protein undergoes complex proteolytic maturation, producing multiple processed forms that bind and activate VEGFR-2 and VEGFR-3, so check which form an assay detects.
VEGF-D belongs to the PDGF/VEGF growth factor family and is structurally and functionally similar to vascular endothelial growth factor C. Mouse and rat each have a Vegfd ortholog. Check the datasheet of any product for its validated reactivity.
Other VEGF family growth factors, their receptors and related angiogenesis and lymphangiogenesis targets.
Gene and protein annotations from HGNC, NCBI Gene and UniProt O43915; product specifications from Assay Genie datasheets.