VISTA
VISTA (V-set immunoregulatory receptor, encoded by the VSIR gene) is a cell-membrane immunoregulatory receptor that inhibits the T-cell response. It is also known as B7-H5, PD-1H, Dies1, GI24 and SISP1, and belongs to the B7 family. Browse Assay Genie's current range of VISTA research reagents below, or read on for the biology behind the target.
VISTA is an immunoregulatory receptor that inhibits the T-cell response. Gene annotation links it to the regulation of T cell activation and to the negative regulation of cytokine production, placing it among the inhibitory signals that restrain immune activity. The protein is located at the plasma membrane.
Beyond immune regulation, UniProt notes that VISTA may promote differentiation of embryonic stem cells by inhibiting BMP4 signalling, and that it may stimulate MMP14-mediated MMP2 activation. Consistent with this, NCBI Gene lists endopeptidase activator activity, enzyme binding activity and identical protein binding activity, as well as involvement in the positive regulation of collagen catabolic process. VISTA itself is not an enzyme; these annotations describe its interactions with, and effects on, other proteins.
The official HGNC symbol is VSIR, for V-set immunoregulatory receptor, and the gene was previously named chromosome 10 open reading frame 54 (C10orf54). Other names in use include B7-H5, B7H5, PD-1H, Dies1, GI24 and SISP1. HGNC classifies it in the V-set domain containing and B7 family gene groups. The mouse ortholog is Vsir, which is useful for researchers studying the VSIR gene in murine models of immune regulation. Researchers working with a VISTA antibody, VISTA ELISA kit or recombinant VISTA protein will often meet these alternative names in the literature.
VISTA is an immunoregulatory receptor that inhibits the T-cell response, making it a focus for studies of T cell activation.
Gene annotation associates VISTA with negative regulation of cytokine production, relevant to work on how inhibitory receptors shape immune output.
VISTA may promote embryonic stem cell differentiation by inhibiting BMP4 signalling, linking it to developmental biology research.
VISTA may stimulate MMP14-mediated MMP2 activation and is annotated with positive regulation of collagen catabolic process.
VISTA is an immunoregulatory receptor that inhibits the T-cell response. It may also promote differentiation of embryonic stem cells by inhibiting BMP4 signalling, and may stimulate MMP14-mediated MMP2 activation. It is located at the cell membrane.
The HGNC symbol is VSIR (V-set immunoregulatory receptor). Aliases include B7-H5, B7H5, PD-1H, Dies1, GI24, SISP1 and the former name C10orf54, chromosome 10 open reading frame 54. UniProt names it V-type immunoglobulin domain-containing suppressor of T-cell activation.
Yes. The mouse ortholog is Vsir, so findings can be explored in murine systems. VISTA belongs to the B7 family and the V-set domain containing gene group. Check the datasheet of any product for its validated reactivity.
Other B7 family members, immune checkpoint proteins and VISTA pathway partners such as BMP4, MMP14 and MMP2.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9H7M9; product specifications from Assay Genie datasheets.