Angiopoietin-like 3
Angiopoietin-like 3 (ANGPTL3, also known as ANGPT5) is a secreted member of the angiopoietin-like protein family, expressed predominantly in the liver. It is involved in angiogenesis, and its N-terminal chain is important for lipid metabolism. Browse Assay Genie's current range of Angiopoietin-like 3 research reagents below, or read on for the biology behind the target.
Angiopoietin-like 3 is a secreted protein involved in angiogenesis. It binds to endothelial cells through integrin alpha-V/beta-3 (ITGAV:ITGB3), activates the FAK, MAPK and Akt signalling pathways, and induces cell adhesion and cell migration. Secreted from podocytes, it may modulate the properties of glomerular endothelial cells through integrin alpha-V/beta-3 and Akt signalling. It may also increase podocyte motility and induce actin filament rearrangements involving integrin alpha-V/beta-3 and Rac1 activation.
Angiopoietin-like 3 also binds to haematopoietic stem cells (HSC) and is involved in regulating HSC activity, probably through down-regulation of IKZF1/IKAROS. The ANGPTL3 gene encodes a member of a family of secreted proteins that function in angiogenesis. The protein is expressed predominantly in the liver and is processed into an N-terminal chain containing a coiled-coil domain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis.
HGNC places the gene in the receptor ligands, fibrinogen C domain containing and angiopoietin like family groups. The previous symbol ANGPT5 and the name angiopoietin-like 3 are still found in the literature, and UniProt lists the product as angiopoietin-related protein 3. Mutations in this gene cause familial hypobetalipoproteinemia type 2, which makes the angiopoietin-like 3 protein a recurring subject in lipid metabolism research. The mouse ortholog is Angptl3, which supports comparative and in vivo studies.
The N-terminal chain of angiopoietin-like 3 is important for lipid metabolism, and mutations in the gene cause familial hypobetalipoproteinemia type 2.
Angiopoietin-like 3 binds endothelial cells via integrin alpha-V/beta-3 and activates FAK, MAPK and Akt signalling to drive adhesion and migration.
Secreted from podocytes, it may modulate glomerular endothelial cells and podocyte motility through integrin alpha-V/beta-3, Akt and Rac1.
It binds haematopoietic stem cells and is involved in regulating their activity, probably through down-regulation of IKZF1/IKAROS.
Angiopoietin-like 3 is a secreted protein involved in angiogenesis. It binds endothelial cells via integrin alpha-V/beta-3, activates FAK, MAPK and Akt signalling, and induces adhesion and migration. Its N-terminal chain is also important for lipid metabolism. Check the datasheet of any product for its validated reactivity.
ANGPTL3 was previously named ANGPT5 and angiopoietin-like 3; UniProt calls it angiopoietin-related protein 3. The protein is processed into an N-terminal coiled-coil domain-containing chain, linked to lipid metabolism, and a C-terminal fibrinogen chain that may be involved in angiogenesis.
Mutations in the ANGPTL3 gene cause familial hypobetalipoproteinemia type 2. The gene has a mouse ortholog, Angptl3, and the protein is expressed predominantly in the liver. Check the datasheet of any product for its validated reactivity.
Other angiopoietin-like family members that act in angiogenesis and related signalling, with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q9Y5C1; product specifications from Assay Genie datasheets.