Angiopoietin-like 8
Angiopoietin-like 8 (ANGPTL8) is a secreted hormone that acts as a blood lipid regulator by controlling serum triglyceride levels. It is also known as TD26, RIFL and C19orf80, and it belongs to the ANGPTL8 family. Browse Assay Genie's current range of Angiopoietin-like 8 research reagents below, or read on for the biology behind the target.
Angiopoietin-like 8 is a hormone that regulates blood lipids by influencing serum triglyceride levels. It is thought to be involved in the metabolic transition between fasting and refeeding. In the fed state it is required to direct fatty acids to adipose tissue for storage. This places the ANGPTL8 protein at the point where nutritional status and lipid handling meet.
The ANGPTL8 gene encodes a secreted protein, and the gene product is located in the extracellular region. NCBI Gene summarises its role as predicted to enable hormone activity and as involved in the regulation of lipid metabolic process and triglyceride homeostasis. It also acts upstream of or within positive regulation of protein processing and regulation of lipoprotein metabolic process. Researchers measuring circulating levels with an ANGPTL8 antibody or ANGPTL8 ELISA kit are typically studying these lipid and lipoprotein pathways.
The gene was previously designated chromosome 19 open reading frame 80 (C19orf80) and has also been called TD26 and RIFL. HGNC now lists it as angiopoietin like 8 within the angiopoietin like family. UniProt, however, places the protein in its own ANGPTL8 family. The mouse ortholog is Angptl8, which allows the biology of this hormone to be studied in rodent models.
ANGPTL8 regulates lipid metabolic processes and is a blood lipid regulator, making it relevant to studies of how lipids are handled in the body.
The hormone regulates serum triglyceride levels, so it is a focus for work on triglyceride homeostasis.
ANGPTL8 may be involved in the metabolic transition between fasting and refeeding, directing fatty acids to adipose tissue in the fed state.
Annotated as acting within regulation of lipoprotein metabolic process, ANGPTL8 is relevant to investigations of lipoprotein biology.
ANGPTL8 is a secreted hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. It may be involved in the metabolic transition between fasting and refeeding and is required to direct fatty acids to adipose tissue for storage in the fed state.
ANGPTL8 is also known as TD26, RIFL and C19orf80. Its previous HGNC names were chromosome 19 open reading frame 80 and angiopoietin-like 8. UniProt lists the protein name as angiopoietin-like protein 8 and assigns it to the ANGPTL8 family.
A mouse ortholog, Angptl8, is recognised for the human gene. This allows the function of the hormone in lipid metabolism to be explored in mouse models. Check the datasheet of any product for its validated reactivity.
Other members of the angiopoietin-like family studied alongside ANGPTL8 in lipid and metabolic research.
Gene and protein annotations from HGNC, NCBI Gene and UniProt Q6UXH0; product specifications from Assay Genie datasheets.