ANXA5
ANXA5 (annexin A5) is a calcium-dependent phospholipid-binding protein of the annexin family that acts as an anticoagulant in the blood coagulation cascade. It is also known as CPB-I, PAP-I, VAC-alpha, ENX2 and ANX5. Browse Assay Genie's current range of ANXA5 research reagents below, or read on for the biology behind the target.
ANXA5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. It belongs to the annexin family of calcium-dependent phospholipid-binding proteins, some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways.
According to the NCBI Gene summary, annexin A5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity. It has a potential role in cellular signal transduction, inflammation, growth and differentiation. The ANXA5 gene contains 13 exons and encodes a single transcript of approximately 1.6 kb. The encoded protein has a molecular weight of about 35 kDa. HGNC places it in the annexin gene group, and mouse and rat each have an ortholog named Anxa5.
The protein has accumulated many names. Annexin A5 has been described as placental anticoagulant protein I (PAP-I), vascular anticoagulant-alpha (VAC-alpha), endonexin II, lipocortin V, placental protein 4 and anchorin CII. Other symbols include CPB-I, ENX2, ANX5 and RPRGL3. The last of these reflects the link between polymorphisms in this gene and various obstetric complications. Researchers studying coagulation, membrane biology and pregnancy-related disorders therefore work with ANXA5 as both a mechanistic target and a disease-associated gene.
ANXA5 is an anticoagulant protein that indirectly inhibits the thromboplastin-specific complex within the blood coagulation cascade.
Annexins bind phospholipids in a calcium-dependent manner and some are implicated in membrane events along exocytotic and endocytotic pathways.
Annexin A5 inhibits phospholipase A2 and protein kinase C and has a potential role in signal transduction, inflammation, growth and differentiation.
Polymorphisms in the ANXA5 gene have been implicated in various obstetric complications, making it a focus for pregnancy-related genetic research.
ANXA5 is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex in the blood coagulation cascade. It also inhibits phospholipase A2 and protein kinase C, shows calcium channel activity, and may contribute to signal transduction, inflammation, growth and differentiation.
Aliases include CPB-I, PAP-I, VAC-alpha, RPRGL3, ENX2 and ANX5. Descriptive names include placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Searching across these terms helps when comparing older literature.
Mouse and rat both have an ortholog named Anxa5, so rodent models can be used to study it; check the datasheet of any product for its validated reactivity. Polymorphisms in the human gene have been implicated in various obstetric complications.
Other members of the annexin family of calcium-dependent phospholipid-binding proteins with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P08758; product specifications from Assay Genie datasheets.