c-Myc
c-Myc (MYC proto-oncogene, bHLH transcription factor; also bHLHe39 or MYCC) is a nuclear phosphoprotein and basic helix-loop-helix transcription factor. It activates growth-related genes and plays a role in cell cycle progression, apoptosis and cellular transformation. Browse Assay Genie's current range of c-Myc research reagents below, or read on for the biology behind the target.
c-Myc is a transcription factor that binds DNA in a non-specific manner, yet also specifically recognises the core sequence 5'-CAC[GA]TG-3', the E box consensus. It forms a heterodimer with the related transcription factor MAX, and this complex regulates transcription of specific target genes. c-Myc activates the transcription of growth-related genes and works with TAF6L to drive target gene expression through RNA polymerase II pause release.
The protein has several defined roles in cell biology. It binds the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. It is a regulator of somatic reprogramming and controls self-renewal of embryonic stem cells. It also positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1. These splicing factors bind repressively to sequences flanking PKM exon 9, inhibiting its inclusion and favouring exon 10 inclusion, which produces the PKM M2 isoform of pyruvate kinase.
The MYC gene belongs to the basic helix-loop-helix group of proteins and was previously named v-myc avian myelocytomatosis viral oncogene homolog. Its protein localises mainly to the nucleus, including the nucleoplasm and nucleolus, with additional reports in the cytoplasm and on chromosomes. Translation can start at an upstream in-frame non-AUG (CUG) site or a downstream AUG site, giving two isoforms with distinct N-termini. Amplification of the gene is frequently observed in numerous human cancers, and translocations involving it are associated with Burkitt lymphoma and multiple myeloma. Mouse and rat each carry a Myc ortholog, which allows comparative work in standard model systems.
Amplification of the MYC gene is frequently observed in human cancers, and translocations are linked to Burkitt lymphoma and multiple myeloma.
c-Myc pairs with MAX to bind E box sequences and regulates target genes, including through RNA polymerase II pause release with TAF6L.
c-Myc regulates somatic reprogramming and controls self-renewal of embryonic stem cells.
c-Myc promotes VEGFA production and sprouting angiogenesis, and drives PKM M2 isoform production via HNRNPA1, HNRNPA2 and PTBP1.
c-Myc is a transcription factor that heterodimerises with MAX and binds E box DNA to regulate target genes. It activates growth-related genes and plays a role in cell cycle progression, apoptosis and cellular transformation. It also promotes VEGFA expression and controls embryonic stem cell self-renewal.
The gene symbol is MYC, with aliases c-Myc, bHLHe39 and MYCC. It was formerly called v-myc avian myelocytomatosis viral oncogene homolog. Translation starts at either a CUG or an AUG codon, producing two isoforms with distinct N-termini.
Amplification of MYC is frequently seen in human cancers, and translocations are associated with Burkitt lymphoma and multiple myeloma. Mouse and rat have Myc orthologs. For any product, check the datasheet of any product for its validated reactivity.
A related MYC-family transcription factor with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P01106; product specifications from Assay Genie datasheets.