CD30 Ligand
CD30 Ligand (TNFSF8, also known as CD153 and CD30LG) is a membrane-bound cytokine of the tumour necrosis factor family. It binds TNFRSF8/CD30 and induces proliferation of T-cells. Browse Assay Genie's current range of CD30 Ligand research reagents below, or read on for the biology behind the target.
CD30 Ligand is a cytokine that binds TNFRSF8/CD30 and induces proliferation of T-cells. CD30 is a cell surface antigen, and it is a marker for Hodgkin lymphoma and related haematological malignancies. When CD30 Ligand is expressed on the B cell surface, its engagement plays an inhibitory role in modulating immunoglobulin class switch.
The TNFSF8 gene encodes a protein that belongs to the tumour necrosis factor (TNF) ligand family and is found at the cell membrane. HGNC lists it in the CD molecules and tumour necrosis factor superfamily gene groups. Two transcript variants encoding different isoforms have been reported for the gene. A mouse ortholog, Tnfsf8, is recorded. Researchers studying the CD30 Ligand protein or the TNFSF8 gene can therefore follow the same ligand-receptor axis across species.
The protein is known by several names. The approved HGNC name is TNF superfamily member 8, and the earlier name was tumour necrosis factor (ligand) superfamily, member 8. CD153 and CD30LG are used as aliases. NCBI Gene notes that CD30 Ligand has pleiotropic activities on different CD30-positive lymphoma cell lines. It enhances proliferation in some lines, while inducing cell death and reducing proliferation in others. This may play a pathophysiological role in Hodgkin's lymphoma and some non-Hodgkin's lymphomas.
CD30 Ligand acts on CD30-positive lymphoma cell lines and may play a pathophysiological role in Hodgkin's and some non-Hodgkin's lymphomas.
As a cytokine that binds TNFRSF8/CD30, CD30 Ligand induces proliferation of T-cells, making it relevant to T-cell biology.
CD30 Ligand engagement on the B cell surface plays an inhibitory role in modulating immunoglobulin class switch.
CD30 Ligand is a TNF family member and the ligand for CD30, so it is useful for studying ligand-receptor pairing in this superfamily.
CD30 Ligand is a cytokine that binds TNFRSF8/CD30 and induces proliferation of T-cells. When it is expressed on B cells, its engagement plays an inhibitory role in modulating immunoglobulin class switch. Its effects on CD30-positive lymphoma cell lines vary between lines.
The gene symbol is TNFSF8, and the HGNC name is TNF superfamily member 8. Aliases include CD153 and CD30LG. The earlier name was tumour necrosis factor (ligand) superfamily, member 8. Two transcript variants encoding different isoforms have been described.
NCBI Gene reports that its varied effects on CD30-positive lymphoma cell lines may play a pathophysiological role in Hodgkin's and some non-Hodgkin's lymphomas. A mouse ortholog, Tnfsf8, exists; check the datasheet of any product for its validated reactivity.
Other TNF superfamily ligands with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P32971; product specifications from Assay Genie datasheets.