CHGA
CHGA (chromogranin A, also known as PHE5 or PHES) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in the secretory vesicles of neurons and endocrine cells, where it regulates granule biogenesis and acts as a precursor to several bioactive peptides. Browse Assay Genie's current range of CHGA research reagents below, or read on for the biology behind the target.
CHGA regulates granule biogenesis in endocrine cells. It up-regulates transcription of protease nexin 1 (SERPINE2) through a cAMP-PKA-SP1 pathway. This in turn inhibits the degradation of granule proteins in the Golgi complex, which promotes granule formation.
The CHGA gene encodes a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins, classified by HGNC within the granins and neuropeptides gene groups. The protein is found in secretory vesicles of neurons and endocrine cells, including neuronal dense core vesicles, and is also secreted. Two transcript variants encoding different isoforms have been reported. Mouse and rat both have a Chga ortholog.
The CHGA gene product is a precursor to three biologically active peptides: vasostatin, pancreastatin and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two further peptides derived from the precursor, catestatin and chromofungin, have antimicrobial and antifungal activity respectively. This makes chromogranin A a useful subject for studies of neuroendocrine secretion, secretory granule biology and peptide processing.
CHGA is a secretory protein of neurons and endocrine cells, and its peptides act as negative modulators of the neuroendocrine system.
CHGA promotes granule formation in endocrine cells by up-regulating SERPINE2 and limiting granule protein degradation in the Golgi complex.
The precursor yields vasostatin, pancreastatin, parastatin, catestatin and chromofungin, making it a model for studying peptide cleavage and function.
Catestatin and chromofungin, derived from chromogranin A, have antimicrobial and antifungal activity respectively.
CHGA regulates granule biogenesis in endocrine cells. It raises transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway, which reduces granule protein degradation in the Golgi complex and so promotes granule formation. It is also a precursor to several bioactive peptides.
CHGA encodes chromogranin A, with the aliases PHE5 and PHES. The precursor gives rise to vasostatin, pancreastatin and parastatin, which modulate the neuroendocrine system negatively, plus catestatin (antimicrobial) and chromofungin (antifungal). Two transcript variants encode different isoforms.
Yes. Mouse and rat each have an ortholog named Chga, so the protein can be studied in common rodent models. As with any reagent, check the datasheet of any product for its validated reactivity.
Other granins, secretory pathway proteins and neuroendocrine markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P10645; product specifications from Assay Genie datasheets.