CXCL5
CXCL5 (C-X-C motif chemokine ligand 5), also known as ENA-78 or SCYB5, is a secreted CXC chemokine involved in neutrophil activation. It is proposed to signal through the G-protein coupled receptor CXCR2 to recruit neutrophils and shape tissue responses. Browse Assay Genie's current range of CXCL5 research reagents below, or read on for the biology behind the target.
CXCL5 is a member of the CXC subfamily of chemokines, a group of small secreted proteins that recruit and activate leukocytes. Chemokines can be classified by function, as inflammatory or homeostatic, or by structure. The CXCL5 protein is involved in neutrophil activation and is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2, CXCR2, to recruit neutrophils, promote angiogenesis and remodel connective tissues.
UniProt places the protein in the intercrine alpha (chemokine CxC) family, and it is a secreted product. Processed forms are of interest: in vitro, the truncated forms ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. This indicates that the activity of CXCL5 can depend on how the mature chemokine is processed. Researchers studying the CXCL5 protein therefore often consider which form is being measured or applied.
The CXCL5 gene is classed by HGNC within the chemokine ligands group. Its names reflect its history: ENA-78 stands for epithelial-derived neutrophil-activating peptide 78, and SCYB5 comes from the earlier small inducible cytokine subfamily B (Cys-X-Cys), member 5 nomenclature. The protein is also thought to play a role in cancer cell proliferation, migration and invasion, which makes it a topic in both inflammation and tumour biology. Mouse and rat each have a Cxcl5 ortholog.
CXCL5 is involved in neutrophil activation and is proposed to recruit neutrophils through CXCR2, making it a focus in leukocyte chemotaxis studies.
As a CXC chemokine that recruits and activates leukocytes, CXCL5 is studied alongside related chemokines to understand inflammatory signalling.
CXCL5 is proposed to promote angiogenesis, so it is investigated in studies of new blood vessel formation.
CXCL5 is thought to play a role in cancer cell proliferation, migration and invasion, and is examined in tumour biology.
CXCL5 is a secreted CXC chemokine involved in neutrophil activation. It is proposed to bind CXCR2 to recruit neutrophils, promote angiogenesis and remodel connective tissues. It is also thought to play a role in cancer cell proliferation, migration and invasion.
CXCL5 is also called ENA-78 and SCYB5. Earlier names include epithelial-derived neutrophil-activating peptide 78, small inducible cytokine subfamily B (Cys-X-Cys) member 5, and chemokine (C-X-C motif) ligand 5. The truncated forms ENA-78(8-78) and ENA-78(9-78) have also been described.
Yes. Both mouse and rat have an ortholog named Cxcl5. Human CXCL5 belongs to the intercrine alpha (CXC) chemokine family. For cross-species work, check the datasheet of any product for its validated reactivity.
Other CXC chemokines with related roles in leukocyte recruitment, inflammation and angiogenesis.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P42830; product specifications from Assay Genie datasheets.