Decorin
Decorin (DCN) is a secreted small leucine-rich proteoglycan of the extracellular matrix, also known as DSPG2 or SLRR1B. It contributes to collagen fibril assembly and, through cell surface receptors, to tumour suppression. Browse Assay Genie's current range of Decorin research reagents below, or read on for the biology behind the target.
Decorin is a secreted proteoglycan found in the extracellular space and extracellular matrix. It plays a role in collagen fibril assembly, and UniProt notes that it may affect the rate of fibril formation. Beyond this structural role, decorin binds multiple cell surface receptors. Through these interactions it mediates tumour suppression, with a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis.
The DCN gene encodes a member of the small leucine-rich proteoglycan (SLRP) family, and decorin belongs to the SLRP class I subfamily. HGNC places it in the small leucine rich repeat proteoglycans gene group. Alternative splicing produces multiple transcript variants. At least one of these encodes a preproprotein, which is proteolytically processed to give the mature protein. Mouse and rat both carry a corresponding Dcn ortholog.
The related gene biglycan is thought to have arisen with DCN through a gene duplication. Decorin has also been known as DSPG2 and SLRR1B. In human patients, mutations in the decorin gene are associated with congenital stromal corneal dystrophy, which links the protein's matrix function to corneal tissue integrity. Researchers studying matrix biology, fibrosis-independent tumour signalling and autophagy use decorin as a model SLRP, and the decorin protein is a frequent subject of antibody- and ELISA-based studies.
Decorin plays a role in collagen fibril assembly and may affect the rate of fibril formation in the extracellular matrix.
Decorin binds multiple cell surface receptors to mediate tumour suppression, including an inhibitory effect on tumorigenesis.
Receptor binding by decorin inhibits angiogenesis and stimulates autophagy and inflammation, making it relevant to these signalling studies.
Mutations in the decorin gene are associated with congenital stromal corneal dystrophy in human patients.
Decorin plays a role in collagen fibril assembly and may affect the rate of fibril formation. It also binds multiple cell surface receptors, mediating tumour suppression through stimulation of autophagy and inflammation and inhibition of angiogenesis and tumorigenesis.
Decorin is encoded by DCN and is also called DSPG2 or SLRR1B. Alternative splicing gives multiple transcript variants, and at least one encodes a preproprotein that is proteolytically processed into the mature protein.
Mouse and rat both have a Dcn ortholog; check the datasheet of any product for its validated reactivity. Decorin gene mutations are associated with congenital stromal corneal dystrophy in humans. DCN and biglycan likely arose by gene duplication.
Biglycan and other small leucine-rich proteoglycans, collagen matrix proteins and tumour-suppression markers with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P07585; product specifications from Assay Genie datasheets.