ENO1
ENO1 (enolase 1) encodes alpha-enolase, one of three enolase isoenzymes in mammals and a member of the enolase family. It acts as a glycolytic enzyme, and a shorter isoform, also known as MBP-1, binds the c-myc promoter and may act as a tumour suppressor. Browse Assay Genie's current range of ENO1 research reagents below, or read on for the biology behind the target.
ENO1 encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of two alpha, two gamma or two beta subunits, and functions as a glycolytic enzyme (EC 4.2.1.11). Alpha-enolase also has roles beyond metabolism: in its monomeric form it serves as a structural lens protein, tau-crystallin, and UniProt records that it binds to the myc promoter and acts as a transcriptional repressor.
The ENO1 gene belongs to the enolase family and is listed by HGNC in the enolases gene group, and also among microRNA protein coding host genes. Alternative splicing produces a shorter isoform, known as MBP-1, that has been shown to bind to the c-myc promoter and function as a tumour suppressor. UniProt notes that the protein may be a tumour suppressor. The protein is reported in the cytoplasm, at the cell membrane, in the nucleus and at the M line of the sarcomere in myofibrils. Several pseudogenes have been identified, including one on the long arm of chromosome 1.
Alpha-enolase has also been identified as an autoantigen in Hashimoto encephalopathy. Aliases and previous symbols include PPH, MBP-1, ENO1L1, MPB1 and ENO1-IT1, and the previous name was enolase 1, (alpha). Mouse and rat both carry an orthologous Eno1 gene, so the target can be studied across common model systems.
ENO1 encodes alpha-enolase, a glycolytic enzyme, making it a reference point for studies of enolase isoenzymes and glycolytic function.
A shorter ENO1 isoform binds the c-myc promoter and acts as a transcriptional repressor, linking this gene to control of myc expression.
The short isoform has been shown to function as a tumour suppressor, and UniProt notes ENO1 may be a tumour suppressor.
Alpha-enolase has been identified as an autoantigen in Hashimoto encephalopathy, which makes it relevant to autoantibody studies.
ENO1 encodes alpha-enolase, which functions as a glycolytic enzyme as part of a homodimer. In its monomeric form it acts as the structural lens protein tau-crystallin. A shorter isoform binds the c-myc promoter and acts as a transcriptional repressor and possible tumour suppressor.
ENO1 is also known as alpha-enolase, PPH, MBP-1, ENO1L1, MPB1 and ENO1-IT1. Alternative splicing gives a shorter isoform that binds the c-myc promoter. Mammals have three enolase isoenzymes, built from alpha, beta or gamma subunits.
Mouse and rat both have an orthologous Eno1 gene; check the datasheet of any product for its validated reactivity. Alpha-enolase has been identified as an autoantigen in Hashimoto encephalopathy, and the short isoform has been linked to tumour suppressor activity.
Other enolase isoenzymes and similarly named targets with products at Assay Genie.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P06733; product specifications from Assay Genie datasheets.