Eotaxin
Eotaxin (C-C motif chemokine ligand 11, encoded by CCL11, also known as SCYA11) is a secreted CC chemokine that drives the migration of eosinophils and other leukocytes. It signals mainly through the CCR3 receptor and has a central role in allergic and non-allergic inflammation. Browse Assay Genie's current range of Eotaxin research reagents below, or read on for the biology behind the target.
Eotaxin is a chemokine that plays a central role in both allergic and non-allergic inflammatory reactions. It induces the migration of several leukocyte types, including eosinophils, basophils, macrophages and dendritic cells, and exerts its effects primarily by binding to the CCR3 receptor. Eotaxin also induces chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway.
The CCL11 gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes, divided into four subfamilies according to the arrangement of the N-terminal cysteine residues of the mature peptide. Eotaxin belongs to the CC subfamily, also called the intercrine beta family, and the HGNC places it in the Eotaxins gene group. The eotaxin protein is secreted. Orthologous genes are named Ccl11 in both mouse and rat.
Eotaxin displays chemotactic activity for eosinophils, but not for mononuclear cells or neutrophils. This eosinophil-specific activity is why it is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. NCBI Gene also describes CCL11 as an antimicrobial gene. Earlier names include small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin), and chemokine (C-C motif) ligand 11; the symbol SCYA11 is a previous symbol for the gene.
Eotaxin is central to allergic reactions, and is thought to contribute to atopic dermatitis, allergic rhinitis and asthma.
Eotaxin is chemotactic for eosinophils but not for mononuclear cells or neutrophils, making it a tool for studying eosinophil recruitment.
Eotaxin acts mainly through CCR3, so it is used to study CCR3-mediated leukocyte migration.
Eotaxin induces endothelial cell chemotaxis and promotes angiogenesis by activating the PI3K/Akt pathway.
Eotaxin is a secreted chemokine that induces migration of eosinophils, basophils, macrophages and dendritic cells, mainly by binding CCR3. It plays a central role in allergic and non-allergic inflammation, and also promotes endothelial chemotaxis and angiogenesis through the PI3K/Akt pathway.
Eotaxin is the product of the CCL11 gene, named C-C motif chemokine ligand 11 by HGNC. Aliases and previous symbols include SCYA11 and MGC22554. Earlier names were small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin) and chemokine (C-C motif) ligand 11.
Mouse and rat both have an orthologous Ccl11 gene. Eotaxin is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. Check the datasheet of any product for its validated reactivity.
Other CC chemokines, including a fellow member of the eotaxin group, involved in leukocyte migration and inflammatory signalling.
Gene and protein annotations from HGNC, NCBI Gene and UniProt P51671; product specifications from Assay Genie datasheets.